Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency

Mikkel Andreassen; Henrik Vestergaard; Lars Østergaard Kristensen

doi:10.1111/j.1365-2265.2007.02986.x

Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency

Mikkel Andreassen, Henrik Vestergaard, Lars Østergaard Kristensen

19 Citationer (Scopus)

Abstract

Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.

Originalsprog	Engelsk
Tidsskrift	Clinical Endocrinology
Vol/bind	67
Udgave nummer	6
Sider (fra-til)	909-16
Antal sider	8
ISSN	0300-0664
DOI	https://doi.org/10.1111/j.1365-2265.2007.02986.x
Status	Udgivet - dec. 2007

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10.1111/j.1365-2265.2007.02986.x

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Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency. / Andreassen, Mikkel ; Vestergaard, Henrik; Kristensen, Lars Østergaard.

I: Clinical Endocrinology, Bind 67, Nr. 6, 12.2007, s. 909-16.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency",

abstract = "Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.",

keywords = "Acromegaly, Adipokines, Adolescent, Adult, C-Reactive Protein, Case-Control Studies, Dwarfism, Pituitary, Female, Human Growth Hormone, Humans, Insulin-Like Growth Factor I, Interleukin-6, Lectins, Male, Middle Aged, Young Adult",

author = "Mikkel Andreassen and Henrik Vestergaard and Kristensen, {Lars {\O}stergaard}",

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T1 - Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency

AU - Andreassen, Mikkel

AU - Vestergaard, Henrik

AU - Kristensen, Lars Østergaard

PY - 2007/12

Y1 - 2007/12

N2 - Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.

AB - Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.

KW - Acromegaly

KW - Adipokines

KW - Adolescent

KW - Adult

KW - C-Reactive Protein

KW - Case-Control Studies

KW - Dwarfism, Pituitary

KW - Female

KW - Human Growth Hormone

KW - Humans

KW - Insulin-Like Growth Factor I

KW - Interleukin-6

KW - Lectins

KW - Male

KW - Middle Aged

KW - Young Adult

U2 - 10.1111/j.1365-2265.2007.02986.x

DO - 10.1111/j.1365-2265.2007.02986.x

M3 - Journal article

C2 - 17727678

SN - 0300-0664

VL - 67

SP - 909

EP - 916

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 6

ER -

Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency

Abstract

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