Composite likelihood method for inferring local pedigrees

TY - JOUR

T1 - Composite likelihood method for inferring local pedigrees

AU - Ko, Amy

AU - Nielsen, Rasmus

PY - 2017/8/21

Y1 - 2017/8/21

N2 - Pedigrees contain information about the genealogical relationships among individuals and are of fundamental importance in many areas of genetic studies. However, pedigrees are often unknown and must be inferred from genetic data. Despite the importance of pedigree inference, existing methods are limited to inferring only close relationships or analyzing a small number of individuals or loci. We present a simulated annealing method for estimating pedigrees in large samples of otherwise seemingly unrelated individuals using genome-wide SNP data. The method supports complex pedigree structures such as polygamous families, multi-generational families, and pedigrees in which many of the member individuals are missing. Computational speed is greatly enhanced by the use of a composite likelihood function which approximates the full likelihood. We validate our method on simulated data and show that it can infer distant relatives more accurately than existing methods. Furthermore, we illustrate the utility of the method on a sample of Greenlandic Inuit.

AB - Pedigrees contain information about the genealogical relationships among individuals and are of fundamental importance in many areas of genetic studies. However, pedigrees are often unknown and must be inferred from genetic data. Despite the importance of pedigree inference, existing methods are limited to inferring only close relationships or analyzing a small number of individuals or loci. We present a simulated annealing method for estimating pedigrees in large samples of otherwise seemingly unrelated individuals using genome-wide SNP data. The method supports complex pedigree structures such as polygamous families, multi-generational families, and pedigrees in which many of the member individuals are missing. Computational speed is greatly enhanced by the use of a composite likelihood function which approximates the full likelihood. We validate our method on simulated data and show that it can infer distant relatives more accurately than existing methods. Furthermore, we illustrate the utility of the method on a sample of Greenlandic Inuit.

UR - http://www.scopus.com/inward/record.url?scp=85028803445&partnerID=8YFLogxK

U2 - 10.1371/journal.pgen.1006963

DO - 10.1371/journal.pgen.1006963

M3 - Journal article

C2 - 28827797

AN - SCOPUS:85028803445

SN - 1553-7390

VL - 13

JO - P L o S Genetics

JF - P L o S Genetics

IS - 8

M1 - e1006963

ER -