Comparison of circulating MMP-9, TIMP-1 and CA19-9 in the detection of pancreatic cancer

TY - JOUR

T1 - Comparison of circulating MMP-9, TIMP-1 and CA19-9 in the detection of pancreatic cancer

AU - Jørgensen, Maiken Thyregod

AU - Brunner, Nils

AU - Schaffalitzky de Muckadell, Ove B.

PY - 2010/2

Y1 - 2010/2

N2 - Background/Aim: The performance of the circulating tumor markers carbohydrate antigen 19-9 (CA19-9), matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were evaluated separately and in combination for their potential value in detecting pancreatic ductal adenocarcinoma. Patients and Methods: The patients had symptoms of pancreatic cancer. The discriminative strength of MMP-9 and TIMP-1 were compared to that of CA19-9 using receiver operating characteristics curves, area under the curves (AUC), specificity and sensitivity. Results: The sensitivities of MMP-9, TIMP-1 and CA19-9 in detecting pancreatic ductal adenocarcinoma were 58.82%, 47.1% and 86%, respectively, with specificities of 34.6%, 692% and 73%. The AUCs of MMP-9, TIMP-1 and CA19-9 were 050, 0.64 and 0.84, respectively. Combining the three markers did not significantly improve detection of pancreatic ductal adenocarcinoma compared to CA19-9 used alone. Conclusion: Circulating MMP-9 and TIMP-1 were inferior to CA19-9 as markers for detecting pancreatic ductal adenocarcinoma and did not improve the diagnostic accuracy when combined with CA19-9.

AB - Background/Aim: The performance of the circulating tumor markers carbohydrate antigen 19-9 (CA19-9), matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were evaluated separately and in combination for their potential value in detecting pancreatic ductal adenocarcinoma. Patients and Methods: The patients had symptoms of pancreatic cancer. The discriminative strength of MMP-9 and TIMP-1 were compared to that of CA19-9 using receiver operating characteristics curves, area under the curves (AUC), specificity and sensitivity. Results: The sensitivities of MMP-9, TIMP-1 and CA19-9 in detecting pancreatic ductal adenocarcinoma were 58.82%, 47.1% and 86%, respectively, with specificities of 34.6%, 692% and 73%. The AUCs of MMP-9, TIMP-1 and CA19-9 were 050, 0.64 and 0.84, respectively. Combining the three markers did not significantly improve detection of pancreatic ductal adenocarcinoma compared to CA19-9 used alone. Conclusion: Circulating MMP-9 and TIMP-1 were inferior to CA19-9 as markers for detecting pancreatic ductal adenocarcinoma and did not improve the diagnostic accuracy when combined with CA19-9.

KW - Former LIFE faculty

KW - Pancreatic ductal adenocarcinoma

KW - carbohydrate antigen19-9

KW - matrix metalloproteinase 9

KW - MMP-9

KW - tissue inhibitor of metalloproteinases 1

KW - TIMP-1

KW - receiver operating characteristic (ROC) curves

M3 - Journal article

SN - 0250-7005

VL - 30

SP - 587

EP - 592

JO - Anticancer Research

JF - Anticancer Research

ER -