Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus

Andrea Galli; Jens Bukh

doi:10.1016/j.tim.2014.02.005

Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus

Andrea Galli, Jens Bukh

50 Citationer (Scopus)

Abstract

Genetic recombination is an important evolutionary mechanism for RNA viruses. The significance of this phenomenon for hepatitis C virus (HCV) has recently become evident, with the identification of circulating recombinant forms in HCV-infected individuals and by novel data from studies permitted by advances in HCV cell culture systems and genotyping protocols. HCV is readily able to produce viable recombinants, using replicative and non-replicative molecular mechanisms. However, our knowledge of the required molecular mechanisms remains limited. Understanding how HCV recombines might be instrumental for a better monitoring of global epidemiology, to clarify the virus evolution, and evaluate the impact of recombinant forms on the efficacy of oncoming combination drug therapies. For the latter, frequency and location of recombination events could affect the efficacy of multidrug regimens. This review will focus on current data available on HCV recombination, also in relation to more detailed data from other RNA viruses.

Originalsprog	Engelsk
Tidsskrift	Trends in Microbiology
Vol/bind	22
Udgave nummer	6
Sider (fra-til)	354-64
Antal sider	11
ISSN	0966-842X
DOI	https://doi.org/10.1016/j.tim.2014.02.005
Status	Udgivet - jun. 2014

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10.1016/j.tim.2014.02.005

Citationsformater

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title = "Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus",

abstract = "Genetic recombination is an important evolutionary mechanism for RNA viruses. The significance of this phenomenon for hepatitis C virus (HCV) has recently become evident, with the identification of circulating recombinant forms in HCV-infected individuals and by novel data from studies permitted by advances in HCV cell culture systems and genotyping protocols. HCV is readily able to produce viable recombinants, using replicative and non-replicative molecular mechanisms. However, our knowledge of the required molecular mechanisms remains limited. Understanding how HCV recombines might be instrumental for a better monitoring of global epidemiology, to clarify the virus evolution, and evaluate the impact of recombinant forms on the efficacy of oncoming combination drug therapies. For the latter, frequency and location of recombination events could affect the efficacy of multidrug regimens. This review will focus on current data available on HCV recombination, also in relation to more detailed data from other RNA viruses.",

keywords = "Evolution, Molecular, Hepacivirus, Models, Genetic, Recombination, Genetic, Virus Replication",

author = "Andrea Galli and Jens Bukh",

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T1 - Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus

AU - Galli, Andrea

AU - Bukh, Jens

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N2 - Genetic recombination is an important evolutionary mechanism for RNA viruses. The significance of this phenomenon for hepatitis C virus (HCV) has recently become evident, with the identification of circulating recombinant forms in HCV-infected individuals and by novel data from studies permitted by advances in HCV cell culture systems and genotyping protocols. HCV is readily able to produce viable recombinants, using replicative and non-replicative molecular mechanisms. However, our knowledge of the required molecular mechanisms remains limited. Understanding how HCV recombines might be instrumental for a better monitoring of global epidemiology, to clarify the virus evolution, and evaluate the impact of recombinant forms on the efficacy of oncoming combination drug therapies. For the latter, frequency and location of recombination events could affect the efficacy of multidrug regimens. This review will focus on current data available on HCV recombination, also in relation to more detailed data from other RNA viruses.

AB - Genetic recombination is an important evolutionary mechanism for RNA viruses. The significance of this phenomenon for hepatitis C virus (HCV) has recently become evident, with the identification of circulating recombinant forms in HCV-infected individuals and by novel data from studies permitted by advances in HCV cell culture systems and genotyping protocols. HCV is readily able to produce viable recombinants, using replicative and non-replicative molecular mechanisms. However, our knowledge of the required molecular mechanisms remains limited. Understanding how HCV recombines might be instrumental for a better monitoring of global epidemiology, to clarify the virus evolution, and evaluate the impact of recombinant forms on the efficacy of oncoming combination drug therapies. For the latter, frequency and location of recombination events could affect the efficacy of multidrug regimens. This review will focus on current data available on HCV recombination, also in relation to more detailed data from other RNA viruses.

KW - Evolution, Molecular

KW - Hepacivirus

KW - Models, Genetic

KW - Recombination, Genetic

KW - Virus Replication

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DO - 10.1016/j.tim.2014.02.005

M3 - Journal article

C2 - 24636243

SN - 0966-842X

VL - 22

SP - 354

EP - 364

JO - Trends in Microbiology

JF - Trends in Microbiology

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Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus

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