TY - JOUR
T1 - Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia
AU - Steinberg, Stacy
AU - de Jong, Simone
AU - Irish Schizophrenia Genomics Consortium
AU - Andreassen, Ole A
AU - Werge, Thomas
AU - Børglum, Anders
AU - Mors, Ole
AU - Mortensen, Preben Bo
AU - Gustafsson, Omar
AU - Costas, Javier
AU - Pietiläinen, Olli P H
AU - Demontis, Ditte
AU - Papiol, Sergi
AU - Huttenlocher, Johanna
AU - Mattheisen, Manuel
AU - Breuer, René
AU - Vassos, Evangelos
AU - Giegling, Ina
AU - Fraser, Gillian
AU - Walker, Nicholas
AU - Tuulio-Henriksson, Annamari
AU - Suvisaari, Jaana
AU - Lönnqvist, Jouko
AU - Paunio, Tiina
AU - Agartz, Ingrid
AU - Melle, Ingrid
AU - Djurovic, Srdjan
AU - Strengman, Eric
AU - GROUP
AU - Jürgens, Gesche
AU - Glenthøj, Birte
AU - Terenius, Lars
AU - Hougaard, David M
AU - Orntoft, Torben
AU - Wiuf, Carsten Henrik
AU - Didriksen, Michael
AU - Hollegaard, Mads Vilhelm
AU - Nordentoft, Merete
AU - van Winkel, Ruud
AU - Kenis, Gunter
AU - Abramova, Lilia
AU - Kaleda, Vasily
AU - Arrojo, Manuel
AU - Sanjuán, Julio
AU - Arango, Celso
AU - Sperling, Swetlana
AU - Rossner, Moritz
AU - Ribolsi, Michele
AU - Magni, Valentina
AU - Siracusano, Alberto
AU - Christiansen, Claus
AU - Kiemeney, Lambertus A
AU - Wellcome Trust Case Control Consortium
PY - 2011/10
Y1 - 2011/10
N2 - Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10-9] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10-9).
AB - Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10-9] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10-9).
U2 - 10.1093/hmg/ddr325
DO - 10.1093/hmg/ddr325
M3 - Journal article
C2 - 21791550
SN - 0964-6906
VL - 20
SP - 4076
EP - 4081
JO - Human Molecular Genetics
JF - Human Molecular Genetics
IS - 20
ER -
