Common genetic variation and the control of HIV-1 in humans

J. Fellay; D. Ge; K.V. Shianna; S. Colombo; B. Ledergerber; E.T. Cirulli; T.J. Urban; K. Zhang; C.E. Gumbs; J.P. Smith; A. Castagna; A. Cozzi-Lepri; Luca A. De; P. Easterbrook; H.F. Gunthard; S. Mallal; C. Mussini; J. Dalmau; J. Martinez-Picado; J.M. Miro; N. Obel; S.M. Wolinsky; J.J. Martinson; R. Detels; J.B. Margolick; L.P. Jacobson; P. Descombes; S.E. Antonarakis; J.S. Beckmann; S.J. O'Brien; N.L. Letvin; A.J. McMichael; B.F. Haynes; M. Carrington; S. Feng; A. Telenti; D.B. Goldstein

Common genetic variation and the control of HIV-1 in humans

J. Fellay, D. Ge, K.V. Shianna, S. Colombo, B. Ledergerber, E.T. Cirulli, T.J. Urban, K. Zhang, C.E. Gumbs, J.P. Smith, A. Castagna, A. Cozzi-Lepri, Luca A. De, P. Easterbrook, H.F. Gunthard, S. Mallal, C. Mussini, J. Dalmau, J. Martinez-Picado, J.M. MiroN. Obel, S.M. Wolinsky, J.J. Martinson, R. Detels, J.B. Margolick, L.P. Jacobson, P. Descombes, S.E. Antonarakis, J.S. Beckmann, S.J. O'Brien, N.L. Letvin, A.J. McMichael, B.F. Haynes, M. Carrington, S. Feng, A. Telenti, D.B. Goldstein

304 Citationer (Scopus)

Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians
Udgivelsesdato: 2009/12

Originalsprog	Engelsk
Tidsskrift	PLoS Genetics
Vol/bind	5
Udgave nummer	12
Sider (fra-til)	e1000791-
ISSN	1553-7390
Status	Udgivet - 2009

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Citationsformater

Fellay, J., Ge, D., Shianna, K. V., Colombo, S., Ledergerber, B., Cirulli, E. T., Urban, T. J., Zhang, K., Gumbs, C. E., Smith, J. P., Castagna, A., Cozzi-Lepri, A., De, L. A., Easterbrook, P., Gunthard, H. F., Mallal, S., Mussini, C., Dalmau, J., Martinez-Picado, J., ... Goldstein, D. B. (2009). Common genetic variation and the control of HIV-1 in humans. PLoS Genetics, 5(12), e1000791-.

Fellay, J, Ge, D, Shianna, KV, Colombo, S, Ledergerber, B, Cirulli, ET, Urban, TJ, Zhang, K, Gumbs, CE, Smith, JP, Castagna, A, Cozzi-Lepri, A, De, LA, Easterbrook, P, Gunthard, HF, Mallal, S, Mussini, C, Dalmau, J, Martinez-Picado, J, Miro, JM, Obel, N, Wolinsky, SM, Martinson, JJ, Detels, R, Margolick, JB, Jacobson, LP, Descombes, P, Antonarakis, SE, Beckmann, JS, O'Brien, SJ, Letvin, NL, McMichael, AJ, Haynes, BF, Carrington, M, Feng, S, Telenti, A & Goldstein, DB 2009, 'Common genetic variation and the control of HIV-1 in humans', PLoS Genetics, bind 5, nr. 12, s. e1000791-.

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title = "Common genetic variation and the control of HIV-1 in humans",

abstract = "To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians Udgivelsesdato: 2009/12",

author = "J. Fellay and D. Ge and K.V. Shianna and S. Colombo and B. Ledergerber and E.T. Cirulli and T.J. Urban and K. Zhang and C.E. Gumbs and J.P. Smith and A. Castagna and A. Cozzi-Lepri and De, {Luca A.} and P. Easterbrook and H.F. Gunthard and S. Mallal and C. Mussini and J. Dalmau and J. Martinez-Picado and J.M. Miro and N. Obel and S.M. Wolinsky and J.J. Martinson and R. Detels and J.B. Margolick and L.P. Jacobson and P. Descombes and S.E. Antonarakis and J.S. Beckmann and S.J. O'Brien and N.L. Letvin and A.J. McMichael and B.F. Haynes and M. Carrington and S. Feng and A. Telenti and D.B. Goldstein",

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T1 - Common genetic variation and the control of HIV-1 in humans

AU - Fellay, J.

AU - Ge, D.

AU - Shianna, K.V.

AU - Colombo, S.

AU - Ledergerber, B.

AU - Cirulli, E.T.

AU - Urban, T.J.

AU - Zhang, K.

AU - Gumbs, C.E.

AU - Smith, J.P.

AU - Castagna, A.

AU - Cozzi-Lepri, A.

AU - De, Luca A.

AU - Easterbrook, P.

AU - Gunthard, H.F.

AU - Mallal, S.

AU - Mussini, C.

AU - Dalmau, J.

AU - Martinez-Picado, J.

AU - Miro, J.M.

AU - Obel, N.

AU - Wolinsky, S.M.

AU - Martinson, J.J.

AU - Detels, R.

AU - Margolick, J.B.

AU - Jacobson, L.P.

AU - Descombes, P.

AU - Antonarakis, S.E.

AU - Beckmann, J.S.

AU - O'Brien, S.J.

AU - Letvin, N.L.

AU - McMichael, A.J.

AU - Haynes, B.F.

AU - Carrington, M.

AU - Feng, S.

AU - Telenti, A.

AU - Goldstein, D.B.

N1 - Cochrane: Art. 12 sider

PY - 2009

Y1 - 2009

N2 - To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians Udgivelsesdato: 2009/12

AB - To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians Udgivelsesdato: 2009/12

M3 - Journal article

SN - 1553-7390

VL - 5

SP - e1000791-

JO - P L o S Genetics

JF - P L o S Genetics

IS - 12

ER -