Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

Erling Mellerup; Ole A Andreassen; Bente Bennike; Henrik Dam; Srdjan Djurovic; Thomas Hansen; Martin Balslev Jorgensen; Lars Vedel Kessing; Pernille Koefoed; Ingrid Melle; Ole Mors; Thomas Werge; Gert Lykke Moeller

doi:10.1371/journal.pone.0143432

Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

Erling Mellerup, Ole A Andreassen, Bente Bennike, Henrik Dam, Srdjan Djurovic, Thomas Hansen, Martin Balslev Jorgensen, Lars Vedel Kessing, Pernille Koefoed, Ingrid Melle, Ole Mors, Thomas Werge, Gert Lykke Moeller

4 Citationer (Scopus)

Abstract

The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.

Originalsprog	Engelsk
Artikelnummer	e0143432
Tidsskrift	P L o S One
Vol/bind	10
Udgave nummer	11
Antal sider	7
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0143432
Status	Udgivet - 1 nov. 2015

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10.1371/journal.pone.0143432Licens: CC BY

Citationsformater

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title = "Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons",

abstract = "The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.",

author = "Erling Mellerup and Andreassen, {Ole A} and Bente Bennike and Henrik Dam and Srdjan Djurovic and Thomas Hansen and Jorgensen, {Martin Balslev} and Kessing, {Lars Vedel} and Pernille Koefoed and Ingrid Melle and Ole Mors and Thomas Werge and Moeller, {Gert Lykke}",

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T1 - Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

AU - Mellerup, Erling

AU - Andreassen, Ole A

AU - Bennike, Bente

AU - Dam, Henrik

AU - Djurovic, Srdjan

AU - Hansen, Thomas

AU - Jorgensen, Martin Balslev

AU - Kessing, Lars Vedel

AU - Koefoed, Pernille

AU - Melle, Ingrid

AU - Mors, Ole

AU - Werge, Thomas

AU - Moeller, Gert Lykke

PY - 2015/11/1

Y1 - 2015/11/1

N2 - The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.

AB - The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.

U2 - 10.1371/journal.pone.0143432

DO - 10.1371/journal.pone.0143432

M3 - Journal article

C2 - 26587987

SN - 1932-6203

VL - 10

JO - P L o S One

JF - P L o S One

IS - 11

M1 - e0143432

ER -

Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

Abstract

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