Combinations of genetic data in a study of oral cancer

Erling Thyge Mellerup; Gert Lykke Møller; Pinaki Mondal; Susanta Roychoudhury

doi:10.18632/genesandcancer.79

Combinations of genetic data in a study of oral cancer

Erling Thyge Mellerup, Gert Lykke Møller, Pinaki Mondal, Susanta Roychoudhury

Molecular Neuroscience

4 Citationer (Scopus)

Abstract

In the single locus strategy a number of genetic variants are analyzed, in order to find variants that are distributed significantly different between controls and patients. A supplementary strategy is to analyze combinations of genetic variants. A combination that is the genetic basis for a polygenic disorder will not occur in in control persons genetically unrelated to patients, so the strategy is to analyze combinations of genetic variants present exclusively in patients. In a previous study of oral cancer and leukoplakia 325 SNPs were analyzed. This study has been supplemented with an analysis of combinations of two SNP genotypes from among the 325 SNPs. Two clusters of combinations containing 95 patient specific combinations were significantly associated with oral cancer or leukoplakia. Of 373 patients with oral cancer 205 patients had a number of these 95 combinations in their genome, whereas none of 535 control persons had any of these combinations in their genome.

Originalsprog	Engelsk
Tidsskrift	Genes & Cancer
Vol/bind	6
Udgave nummer	9-10
Sider (fra-til)	422-427
Antal sider	6
ISSN	1947-6019
DOI	https://doi.org/10.18632/genesandcancer.79
Status	Udgivet - sep. 2015

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10.18632/genesandcancer.79Licens: CC BY

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title = "Combinations of genetic data in a study of oral cancer",

abstract = "In the single locus strategy a number of genetic variants are analyzed, in order to find variants that are distributed significantly different between controls and patients. A supplementary strategy is to analyze combinations of genetic variants. A combination that is the genetic basis for a polygenic disorder will not occur in in control persons genetically unrelated to patients, so the strategy is to analyze combinations of genetic variants present exclusively in patients. In a previous study of oral cancer and leukoplakia 325 SNPs were analyzed. This study has been supplemented with an analysis of combinations of two SNP genotypes from among the 325 SNPs. Two clusters of combinations containing 95 patient specific combinations were significantly associated with oral cancer or leukoplakia. Of 373 patients with oral cancer 205 patients had a number of these 95 combinations in their genome, whereas none of 535 control persons had any of these combinations in their genome. ",

author = "Mellerup, {Erling Thyge} and M{\o}ller, {Gert Lykke} and Pinaki Mondal and Susanta Roychoudhury",

year = "2015",

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doi = "10.18632/genesandcancer.79",

language = "English",

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T1 - Combinations of genetic data in a study of oral cancer

AU - Mellerup, Erling Thyge

AU - Møller, Gert Lykke

AU - Mondal, Pinaki

AU - Roychoudhury, Susanta

PY - 2015/9

Y1 - 2015/9

N2 - In the single locus strategy a number of genetic variants are analyzed, in order to find variants that are distributed significantly different between controls and patients. A supplementary strategy is to analyze combinations of genetic variants. A combination that is the genetic basis for a polygenic disorder will not occur in in control persons genetically unrelated to patients, so the strategy is to analyze combinations of genetic variants present exclusively in patients. In a previous study of oral cancer and leukoplakia 325 SNPs were analyzed. This study has been supplemented with an analysis of combinations of two SNP genotypes from among the 325 SNPs. Two clusters of combinations containing 95 patient specific combinations were significantly associated with oral cancer or leukoplakia. Of 373 patients with oral cancer 205 patients had a number of these 95 combinations in their genome, whereas none of 535 control persons had any of these combinations in their genome.

AB - In the single locus strategy a number of genetic variants are analyzed, in order to find variants that are distributed significantly different between controls and patients. A supplementary strategy is to analyze combinations of genetic variants. A combination that is the genetic basis for a polygenic disorder will not occur in in control persons genetically unrelated to patients, so the strategy is to analyze combinations of genetic variants present exclusively in patients. In a previous study of oral cancer and leukoplakia 325 SNPs were analyzed. This study has been supplemented with an analysis of combinations of two SNP genotypes from among the 325 SNPs. Two clusters of combinations containing 95 patient specific combinations were significantly associated with oral cancer or leukoplakia. Of 373 patients with oral cancer 205 patients had a number of these 95 combinations in their genome, whereas none of 535 control persons had any of these combinations in their genome.

U2 - 10.18632/genesandcancer.79

DO - 10.18632/genesandcancer.79

M3 - Journal article

C2 - 26622944

SN - 1947-6019

VL - 6

SP - 422

EP - 427

JO - Genes & Cancer

JF - Genes & Cancer

IS - 9-10

ER -

Combinations of genetic data in a study of oral cancer

Abstract

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