TY - JOUR
T1 - Combinations of genetic data in a study of neuroblastoma risk genotypes
AU - Capasso, Mario
AU - Calabrese, Francesco Maria
AU - Iolascon, Achille
AU - Mellerup, Erling
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014/3
Y1 - 2014/3
N2 - Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).
AB - Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).
KW - Genotype
KW - Humans
KW - Neuroblastoma
KW - Polymorphism, Single Nucleotide
U2 - 10.1016/j.cancergen.2014.02.004
DO - 10.1016/j.cancergen.2014.02.004
M3 - Journal article
C2 - 24726319
SN - 0165-4608
VL - 207
SP - 94
EP - 97
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 3
ER -