Collagenous sprue: a coeliac disease look-alike with different treatment strategy

Christoffer Soendergaard; Lene Buhl Riis; Ole Haagen Nielsen

doi:10.1136/bcr-2014-203721

Collagenous sprue: a coeliac disease look-alike with different treatment strategy

Christoffer Soendergaard, Lene Buhl Riis, Ole Haagen Nielsen

Institut for Klinisk Medicin

4 Citationer (Scopus)

Abstract

Collagenous sprue is a rare clinicopathological condition of the small bowel. It is characterised by abnormal subepithelial collagen deposition and is typically associated with malabsorption, diarrhoea and weight loss. The clinical features of collagenous sprue often resemble those of coeliac disease and together with frequent histological findings like mucosal thinning and intraepithelial lymphocytosis the diagnosis may be hard to reach without awareness of this condition. While coeliac disease is treated using gluten restriction, collagenous sprue is, however, not improved by this intervention. In cases of diet-refractory 'coeliac disease' it is therefore essential to consider collagenous sprue to initiate treatment at an early stage to prevent the fibrotic progression. Here, we report a case of a 78-year-old man with collagenous sprue and present the clinical and histological manifestations as well as the successful treatment course that he underwent.

Originalsprog	Engelsk
Tidsskrift	BMJ Case Reports
Vol/bind	2014
ISSN	1757-790X
DOI	https://doi.org/10.1136/bcr-2014-203721
Status	Udgivet - 28 mar. 2014

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10.1136/bcr-2014-203721

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title = "Collagenous sprue: a coeliac disease look-alike with different treatment strategy",

abstract = "Collagenous sprue is a rare clinicopathological condition of the small bowel. It is characterised by abnormal subepithelial collagen deposition and is typically associated with malabsorption, diarrhoea and weight loss. The clinical features of collagenous sprue often resemble those of coeliac disease and together with frequent histological findings like mucosal thinning and intraepithelial lymphocytosis the diagnosis may be hard to reach without awareness of this condition. While coeliac disease is treated using gluten restriction, collagenous sprue is, however, not improved by this intervention. In cases of diet-refractory 'coeliac disease' it is therefore essential to consider collagenous sprue to initiate treatment at an early stage to prevent the fibrotic progression. Here, we report a case of a 78-year-old man with collagenous sprue and present the clinical and histological manifestations as well as the successful treatment course that he underwent.",

keywords = "Aged, Budesonide, Calcium, Celiac Disease, Collagenous Sprue, Diagnosis, Differential, Dietary Supplements, Glucocorticoids, Humans, Male, Vitamin D, Vitamins",

author = "Christoffer Soendergaard and Riis, {Lene Buhl} and Nielsen, {Ole Haagen}",

year = "2014",

month = mar,

day = "28",

doi = "10.1136/bcr-2014-203721",

language = "English",

volume = "2014",

journal = "BMJ Case Reports",

issn = "1757-790X",

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TY - JOUR

T1 - Collagenous sprue

T2 - a coeliac disease look-alike with different treatment strategy

AU - Soendergaard, Christoffer

AU - Riis, Lene Buhl

AU - Nielsen, Ole Haagen

PY - 2014/3/28

Y1 - 2014/3/28

N2 - Collagenous sprue is a rare clinicopathological condition of the small bowel. It is characterised by abnormal subepithelial collagen deposition and is typically associated with malabsorption, diarrhoea and weight loss. The clinical features of collagenous sprue often resemble those of coeliac disease and together with frequent histological findings like mucosal thinning and intraepithelial lymphocytosis the diagnosis may be hard to reach without awareness of this condition. While coeliac disease is treated using gluten restriction, collagenous sprue is, however, not improved by this intervention. In cases of diet-refractory 'coeliac disease' it is therefore essential to consider collagenous sprue to initiate treatment at an early stage to prevent the fibrotic progression. Here, we report a case of a 78-year-old man with collagenous sprue and present the clinical and histological manifestations as well as the successful treatment course that he underwent.

AB - Collagenous sprue is a rare clinicopathological condition of the small bowel. It is characterised by abnormal subepithelial collagen deposition and is typically associated with malabsorption, diarrhoea and weight loss. The clinical features of collagenous sprue often resemble those of coeliac disease and together with frequent histological findings like mucosal thinning and intraepithelial lymphocytosis the diagnosis may be hard to reach without awareness of this condition. While coeliac disease is treated using gluten restriction, collagenous sprue is, however, not improved by this intervention. In cases of diet-refractory 'coeliac disease' it is therefore essential to consider collagenous sprue to initiate treatment at an early stage to prevent the fibrotic progression. Here, we report a case of a 78-year-old man with collagenous sprue and present the clinical and histological manifestations as well as the successful treatment course that he underwent.

KW - Aged

KW - Budesonide

KW - Calcium

KW - Celiac Disease

KW - Collagenous Sprue

KW - Diagnosis, Differential

KW - Dietary Supplements

KW - Glucocorticoids

KW - Humans

KW - Male

KW - Vitamin D

KW - Vitamins

U2 - 10.1136/bcr-2014-203721

DO - 10.1136/bcr-2014-203721

M3 - Journal article

C2 - 24682141

SN - 1757-790X

VL - 2014

JO - BMJ Case Reports

JF - BMJ Case Reports

ER -

Collagenous sprue: a coeliac disease look-alike with different treatment strategy

Abstract

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