Cognitive effects of six months of treatment with quetiapine in antipsychotic-naïve first-episode schizophrenia

TY - JOUR

T1 - Cognitive effects of six months of treatment with quetiapine in antipsychotic-naïve first-episode schizophrenia

AU - Andersen, Rune

AU - Fagerlund, Birgitte

AU - Rasmussen, Hans

AU - Ebdrup, Bjorn H

AU - Aggernaes, Bodil

AU - Gade, Anders

AU - Oranje, Bob

AU - Glenthøj, Birte Yding

N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.

PY - 2011/5/15

Y1 - 2011/5/15

N2 - Effects of quetiapine on cognition were assessed in a group of first-episode antipsychotic-naïve patients with schizophrenia (N=24). A comprehensive battery of neuropsychological tests was administered at baseline and after 6months of treatment with quetiapine. In order to examine retest effects, a matched healthy control group (N=24) was also tested at baseline and after 6months. Only few differential changes were observed between patients and healthy controls. Of 8 cognitive domains examined, only significant changes in executive function suggested possible ameliorating effects of quetiapine. Patients also improved on speed of processing; however, this was parallel to the retest effects found in healthy controls. When covaried for differences at baseline, patients showed smaller improvements in speed of processing than the retest effects found in controls, as well as a lack of retest effects on sustained attention and working memory that were found in healthy controls. The main result of the study is that there was very little evidence of efficacy of quetiapine on cognition. The study also indicated a lack of normal retest effects in patients compared to controls.

AB - Effects of quetiapine on cognition were assessed in a group of first-episode antipsychotic-naïve patients with schizophrenia (N=24). A comprehensive battery of neuropsychological tests was administered at baseline and after 6months of treatment with quetiapine. In order to examine retest effects, a matched healthy control group (N=24) was also tested at baseline and after 6months. Only few differential changes were observed between patients and healthy controls. Of 8 cognitive domains examined, only significant changes in executive function suggested possible ameliorating effects of quetiapine. Patients also improved on speed of processing; however, this was parallel to the retest effects found in healthy controls. When covaried for differences at baseline, patients showed smaller improvements in speed of processing than the retest effects found in controls, as well as a lack of retest effects on sustained attention and working memory that were found in healthy controls. The main result of the study is that there was very little evidence of efficacy of quetiapine on cognition. The study also indicated a lack of normal retest effects in patients compared to controls.

M3 - Journal article

SN - 0165-1781

VL - 187

SP - 49

EP - 54

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1-2

ER -