TY - JOUR
T1 - Clustering of malaria treatment failure (TF) in Daraweesh: hints for host genetic susceptibility to TF with emphasis on immune-modulating SNPs
AU - Giha, Hayder A
AU - ElGhazali, Gehad
AU - Nasr, Amre
AU - Iriemenam, Nnaemeka C
AU - Berzins, Klavs
AU - Troye-Blomberg, Marita
AU - Theander, Thor G
AU - Arnot, David
N1 - Keywords: Adolescent; Adult; Antibodies, Protozoan; Antimalarials; Chi-Square Distribution; Chloroquine; Cluster Analysis; Female; Genetic Predisposition to Disease; Host-Parasite Interactions; Humans; Immunoglobulin G; Malaria, Falciparum; Male; Plasmodium falciparum; Polymorphism, Single Nucleotide; Statistics, Nonparametric; Sudan; Treatment Failure
PY - 2010/5
Y1 - 2010/5
N2 - In malaria, drug resistance and treatment failure (TF) are not synonymous, although are escalating together. Over 9 years of surveillances for malaria morbidity and TF in Daraweesh village in eastern Sudan (1991-2004), 136 donors (15-78 years) from 43 households, treated for 278 malaria episodes and had experienced 46 incident of TF, were included in this study. Blood obtained from the donors in 2005, was used for measurement of IgG subclasses against Pf332-C231 antigen and GM/KM allotyping and for genotyping of the donors for; FcγRIIA 131 (HH, RH, RR), CRP 286 (C
AB - In malaria, drug resistance and treatment failure (TF) are not synonymous, although are escalating together. Over 9 years of surveillances for malaria morbidity and TF in Daraweesh village in eastern Sudan (1991-2004), 136 donors (15-78 years) from 43 households, treated for 278 malaria episodes and had experienced 46 incident of TF, were included in this study. Blood obtained from the donors in 2005, was used for measurement of IgG subclasses against Pf332-C231 antigen and GM/KM allotyping and for genotyping of the donors for; FcγRIIA 131 (HH, RH, RR), CRP 286 (C
U2 - 10.1016/j.meegid.2010.02.013
DO - 10.1016/j.meegid.2010.02.013
M3 - Journal article
C2 - 20215002
SN - 1567-1348
VL - 10
SP - 481
EP - 486
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
IS - 4
ER -
