Clonal outbreaks of [Pasteurella] pneumotropica biovar Heyl in two mouse colonies

Sadhana Adhikary; Magne Bisgaard; Frederik Dagnæs-Hansen; Henrik Christensen

doi:10.1177/0023677217698503

Clonal outbreaks of [Pasteurella] pneumotropica biovar Heyl in two mouse colonies

Sadhana Adhikary^*, Magne Bisgaard, Frederik Dagnæs-Hansen, Henrik Christensen

^*Corresponding author af dette arbejde

8 Citationer (Scopus)

Abstract

The aim of this study was to document the pathogenic role of biovar Heyl of [Pasteurella] pneumotropica in mouse colonies. Fifty-three isolates associated with mastitis and orbital, cutaneous and vaginal abscesses as well as isolates from the nose and vagina of healthy mice were investigated. According to phenotypic characteristics and rpoB sequencing, the isolates were identified as [P.] pneumotropica biovar Heyl. Pulsed-field gel electrophoresis (PFGE) revealed five closely related profiles separated by only one to four fragments. The outbreak strains diverged from epidemiologically unrelated strains with the same rpoB sequence type, as shown by the PFGE profiles. The investigation documented that members of biovar Heyl of [P.] pneumotropica caused disease outbreaks in mouse colonies since the clonality indicated a primary role of [P.] pneumotropica biovar Heyl in the infections observed.

Originalsprog	Engelsk
Tidsskrift	Laboratory Animals
Vol/bind	51
Udgave nummer	6
Sider (fra-til)	613-621
Antal sider	9
ISSN	0023-6772
DOI	https://doi.org/10.1177/0023677217698503
Status	Udgivet - 2017

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10.1177/0023677217698503

Citationsformater

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title = "Clonal outbreaks of [Pasteurella] pneumotropica biovar Heyl in two mouse colonies",

abstract = "The aim of this study was to document the pathogenic role of biovar Heyl of [Pasteurella] pneumotropica in mouse colonies. Fifty-three isolates associated with mastitis and orbital, cutaneous and vaginal abscesses as well as isolates from the nose and vagina of healthy mice were investigated. According to phenotypic characteristics and rpoB sequencing, the isolates were identified as [P.] pneumotropica biovar Heyl. Pulsed-field gel electrophoresis (PFGE) revealed five closely related profiles separated by only one to four fragments. The outbreak strains diverged from epidemiologically unrelated strains with the same rpoB sequence type, as shown by the PFGE profiles. The investigation documented that members of biovar Heyl of [P.] pneumotropica caused disease outbreaks in mouse colonies since the clonality indicated a primary role of [P.] pneumotropica biovar Heyl in the infections observed.",

keywords = "abscess, mice, PFGE, rpoB, [Pasteurella] pneumotropica",

author = "Sadhana Adhikary and Magne Bisgaard and Frederik Dagn{\ae}s-Hansen and Henrik Christensen",

year = "2017",

doi = "10.1177/0023677217698503",

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TY - JOUR

T1 - Clonal outbreaks of [Pasteurella] pneumotropica biovar Heyl in two mouse colonies

AU - Adhikary, Sadhana

AU - Bisgaard, Magne

AU - Dagnæs-Hansen, Frederik

AU - Christensen, Henrik

PY - 2017

Y1 - 2017

N2 - The aim of this study was to document the pathogenic role of biovar Heyl of [Pasteurella] pneumotropica in mouse colonies. Fifty-three isolates associated with mastitis and orbital, cutaneous and vaginal abscesses as well as isolates from the nose and vagina of healthy mice were investigated. According to phenotypic characteristics and rpoB sequencing, the isolates were identified as [P.] pneumotropica biovar Heyl. Pulsed-field gel electrophoresis (PFGE) revealed five closely related profiles separated by only one to four fragments. The outbreak strains diverged from epidemiologically unrelated strains with the same rpoB sequence type, as shown by the PFGE profiles. The investigation documented that members of biovar Heyl of [P.] pneumotropica caused disease outbreaks in mouse colonies since the clonality indicated a primary role of [P.] pneumotropica biovar Heyl in the infections observed.

AB - The aim of this study was to document the pathogenic role of biovar Heyl of [Pasteurella] pneumotropica in mouse colonies. Fifty-three isolates associated with mastitis and orbital, cutaneous and vaginal abscesses as well as isolates from the nose and vagina of healthy mice were investigated. According to phenotypic characteristics and rpoB sequencing, the isolates were identified as [P.] pneumotropica biovar Heyl. Pulsed-field gel electrophoresis (PFGE) revealed five closely related profiles separated by only one to four fragments. The outbreak strains diverged from epidemiologically unrelated strains with the same rpoB sequence type, as shown by the PFGE profiles. The investigation documented that members of biovar Heyl of [P.] pneumotropica caused disease outbreaks in mouse colonies since the clonality indicated a primary role of [P.] pneumotropica biovar Heyl in the infections observed.

KW - abscess

KW - mice

KW - PFGE

KW - rpoB

KW - [Pasteurella] pneumotropica

U2 - 10.1177/0023677217698503

DO - 10.1177/0023677217698503

M3 - Journal article

C2 - 28358244

AN - SCOPUS:85034764363

SN - 0023-6772

VL - 51

SP - 613

EP - 621

JO - Laboratory Animals

JF - Laboratory Animals

IS - 6

ER -

Clonal outbreaks of [Pasteurella] pneumotropica biovar Heyl in two mouse colonies

Abstract

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