Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.

Britta Halvarsson; Harald Anderson; Katarina Domanska; Gudrun Lindmark; Mef Nilbert

doi:10.1309/0PP5GDRTXUDVKAWJ

Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.

Britta Halvarsson, Harald Anderson, Katarina Domanska, Gudrun Lindmark, Mef Nilbert

36 Citationer (Scopus)

Abstract

Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers.
Udgivelsesdato: 2008-Feb

Originalsprog	Engelsk
Tidsskrift	American Journal of Clinical Pathology
Vol/bind	129
Udgave nummer	2
Sider (fra-til)	238-44
Antal sider	6
ISSN	0002-9173
DOI	https://doi.org/10.1309/0PP5GDRTXUDVKAWJ
Status	Udgivet - 2008

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10.1309/0PP5GDRTXUDVKAWJ

Citationsformater

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title = "Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.",

abstract = "Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers. Udgivelsesdato: 2008-Feb",

author = "Britta Halvarsson and Harald Anderson and Katarina Domanska and Gudrun Lindmark and Mef Nilbert",

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T1 - Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.

AU - Halvarsson, Britta

AU - Anderson, Harald

AU - Domanska, Katarina

AU - Lindmark, Gudrun

AU - Nilbert, Mef

PY - 2008

Y1 - 2008

N2 - Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers. Udgivelsesdato: 2008-Feb

AB - Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers. Udgivelsesdato: 2008-Feb

U2 - 10.1309/0PP5GDRTXUDVKAWJ

DO - 10.1309/0PP5GDRTXUDVKAWJ

M3 - Journal article

SN - 0002-9173

VL - 129

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EP - 244

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

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ER -