Clinical PET/MR Imaging in Dementia and Neuro-Oncology

TY - JOUR

T1 - Clinical PET/MR Imaging in Dementia and Neuro-Oncology

AU - Henriksen, Otto M.

AU - Marner, Lisbeth

AU - Law, Ian

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The introduction of hybrid PET/MRI systems allows simultaneous multimodality image acquisition of high technical quality. This technique is well suited for the brain, and particularly in dementia and neuro-oncology. In routine use combinations of well-established MRI sequences and PET tracers provide the most optimal and clinically valuable protocols. For dementia the [18F]-fluorodeoxyglucose (FDG) has merit with a simultaneous four sequence MRI protocol of 20 min supported by supplementary statistical reading tools and quantitative measurements of the hippocampal volume. Clinical PET/MRI using [18F]-fluoro-ethyl-tyrosine (FET) also abide to the expectations of the adaptive and versatile diagnostic tool necessary in neuro-oncology covering both simple 20 min protocols for routine treatment surveillance and complicated 90 min brain and spinal cord protocols in pediatric neuro-oncology under general anesthesia. The clinical value of adding advanced MRI sequences in multiparametric imaging setting, however, is still undocumented.

AB - The introduction of hybrid PET/MRI systems allows simultaneous multimodality image acquisition of high technical quality. This technique is well suited for the brain, and particularly in dementia and neuro-oncology. In routine use combinations of well-established MRI sequences and PET tracers provide the most optimal and clinically valuable protocols. For dementia the [18F]-fluorodeoxyglucose (FDG) has merit with a simultaneous four sequence MRI protocol of 20 min supported by supplementary statistical reading tools and quantitative measurements of the hippocampal volume. Clinical PET/MRI using [18F]-fluoro-ethyl-tyrosine (FET) also abide to the expectations of the adaptive and versatile diagnostic tool necessary in neuro-oncology covering both simple 20 min protocols for routine treatment surveillance and complicated 90 min brain and spinal cord protocols in pediatric neuro-oncology under general anesthesia. The clinical value of adding advanced MRI sequences in multiparametric imaging setting, however, is still undocumented.

KW - Brain

KW - Brain Mapping

KW - Brain Neoplasms

KW - Dementia

KW - Humans

KW - Magnetic Resonance Imaging

KW - Multimodal Imaging

KW - Positron-Emission Tomography

KW - Journal Article

KW - Review

U2 - 10.1016/j.cpet.2016.05.003

DO - 10.1016/j.cpet.2016.05.003

M3 - Review

C2 - 27593248

SN - 1556-8598

VL - 11

SP - 441

EP - 452

JO - P E T Clinics

JF - P E T Clinics

IS - 4

ER -