Classification of iRBD and Parkinson's patients using a general data-driven sleep staging model built on EEG

TY - JOUR

T1 - Classification of iRBD and Parkinson's patients using a general data-driven sleep staging model built on EEG

AU - Koch, Henriette

AU - Christensen, Gitte Julie

AU - Frandsen, Rune Asger Vestergaard

AU - Arvastson, Lars

AU - Christensen, Soren R

AU - Sorensen, Helge B D

AU - Jennum, Poul

PY - 2013

Y1 - 2013

N2 - Sleep analysis is an important diagnostic tool for sleep disorders. However, the current manual sleep scoring is time-consuming as it is a crude discretization in time and stages. This study changes Esbroeck and Westover's [1] latent sleep staging model into a global model. The proposed data-driven method trained a topic mixture model on 10 control subjects and was applied on 10 other control subjects, 10 iRBD patients and 10 Parkinson's patients. In that way 30 topic mixture diagrams were obtained from which features reflecting distinct sleep architectures between control subjects and patients were extracted. Two features calculated on basis of two latent sleep states classified subjects as 'control' or 'patient' by a simple clustering algorithm. The mean sleep staging accuracy compared to classical AASM scoring was 72.4% for control subjects and a clustering of the derived features resulted in a sensitivity of 95% and a specificity of 80 %. This study demonstrates that frequency analysis of sleep EEG can be used for data-driven global sleep classification and that topic features separates iRBD and Parkinson's patients from control subjects.

AB - Sleep analysis is an important diagnostic tool for sleep disorders. However, the current manual sleep scoring is time-consuming as it is a crude discretization in time and stages. This study changes Esbroeck and Westover's [1] latent sleep staging model into a global model. The proposed data-driven method trained a topic mixture model on 10 control subjects and was applied on 10 other control subjects, 10 iRBD patients and 10 Parkinson's patients. In that way 30 topic mixture diagrams were obtained from which features reflecting distinct sleep architectures between control subjects and patients were extracted. Two features calculated on basis of two latent sleep states classified subjects as 'control' or 'patient' by a simple clustering algorithm. The mean sleep staging accuracy compared to classical AASM scoring was 72.4% for control subjects and a clustering of the derived features resulted in a sensitivity of 95% and a specificity of 80 %. This study demonstrates that frequency analysis of sleep EEG can be used for data-driven global sleep classification and that topic features separates iRBD and Parkinson's patients from control subjects.

U2 - 10.1109/embc.2013.6610490

DO - 10.1109/embc.2013.6610490

M3 - Journal article

C2 - 24110677

SN - 0589-1019

VL - 2013

SP - 4275

EP - 4278

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ER -