Circulating Noncoding RNAs as Clinical Biomarkers

Francesco Russo; Flavia Scoyni; Alessandro Fatica; Marco Pellegrini; Alfredo Ferro; Alfredo Pulvirenti; Rosalba Giugno

doi:10.1016/b978-0-12-801899-6.00012-7

Circulating Noncoding RNAs as Clinical Biomarkers

Francesco Russo^*, Flavia Scoyni, Alessandro Fatica, Marco Pellegrini, Alfredo Ferro, Alfredo Pulvirenti, Rosalba Giugno

^*Corresponding author af dette arbejde

4 Citationer (Scopus)

Abstract

Noncoding RNAs (ncRNAs) are frequently dysregulated in cancer and other diseases and have shown great potential as tissue-based markers for cancer classification and prognostication. ncRNAs are present in membrane-bound vesicles, such as exosomes, in extracellular human body fluids. Since microRNAs and the other ncRNAs circulate in the bloodstream in highly stable extracellular forms, they may be used as blood-based biomarkers. The identification and use of noninvasive biomarkers is a fundamental tool for biomedical research, but optimal and standardized conditions for processing blood samples for RNA measurement remain to be established. In this chapter, we discuss recent discoveries and controversial topics on circulating ncRNAs and present several public resources recently developed.

Originalsprog	Engelsk
Titel	Epigenetic Biomarkers and Diagnostics
Antal sider	20
Forlag	Elsevier Science Inc.
Publikationsdato	2016
Sider	239-258
ISBN (Trykt)	9780128018996
ISBN (Elektronisk)	9780128019214
DOI	https://doi.org/10.1016/b978-0-12-801899-6.00012-7
Status	Udgivet - 2016
Udgivet eksternt	Ja

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abstract = "Noncoding RNAs (ncRNAs) are frequently dysregulated in cancer and other diseases and have shown great potential as tissue-based markers for cancer classification and prognostication. ncRNAs are present in membrane-bound vesicles, such as exosomes, in extracellular human body fluids. Since microRNAs and the other ncRNAs circulate in the bloodstream in highly stable extracellular forms, they may be used as blood-based biomarkers. The identification and use of noninvasive biomarkers is a fundamental tool for biomedical research, but optimal and standardized conditions for processing blood samples for RNA measurement remain to be established. In this chapter, we discuss recent discoveries and controversial topics on circulating ncRNAs and present several public resources recently developed.",

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T1 - Circulating Noncoding RNAs as Clinical Biomarkers

AU - Russo, Francesco

AU - Scoyni, Flavia

AU - Fatica, Alessandro

AU - Pellegrini, Marco

AU - Ferro, Alfredo

AU - Pulvirenti, Alfredo

AU - Giugno, Rosalba

PY - 2016

Y1 - 2016

N2 - Noncoding RNAs (ncRNAs) are frequently dysregulated in cancer and other diseases and have shown great potential as tissue-based markers for cancer classification and prognostication. ncRNAs are present in membrane-bound vesicles, such as exosomes, in extracellular human body fluids. Since microRNAs and the other ncRNAs circulate in the bloodstream in highly stable extracellular forms, they may be used as blood-based biomarkers. The identification and use of noninvasive biomarkers is a fundamental tool for biomedical research, but optimal and standardized conditions for processing blood samples for RNA measurement remain to be established. In this chapter, we discuss recent discoveries and controversial topics on circulating ncRNAs and present several public resources recently developed.

AB - Noncoding RNAs (ncRNAs) are frequently dysregulated in cancer and other diseases and have shown great potential as tissue-based markers for cancer classification and prognostication. ncRNAs are present in membrane-bound vesicles, such as exosomes, in extracellular human body fluids. Since microRNAs and the other ncRNAs circulate in the bloodstream in highly stable extracellular forms, they may be used as blood-based biomarkers. The identification and use of noninvasive biomarkers is a fundamental tool for biomedical research, but optimal and standardized conditions for processing blood samples for RNA measurement remain to be established. In this chapter, we discuss recent discoveries and controversial topics on circulating ncRNAs and present several public resources recently developed.

KW - Biomarkers

KW - Circular RNAs

KW - Circulating microRNAs

KW - Database

KW - Long noncoding RNAs

KW - Noncoding RNAs

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DO - 10.1016/b978-0-12-801899-6.00012-7

M3 - Book chapter

SN - 9780128018996

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BT - Epigenetic Biomarkers and Diagnostics

PB - Elsevier Science Inc.

ER -

Circulating Noncoding RNAs as Clinical Biomarkers

Abstract

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