Circulating metabolites associated with alcohol intake in the European prospective investigation into cancer and nutrition cohort

TY - JOUR

T1 - Circulating metabolites associated with alcohol intake in the European prospective investigation into cancer and nutrition cohort

AU - van Roekel, Eline H

AU - Trijsburg, Laura

AU - Assi, Nada

AU - Carayol, Marion

AU - Achaintre, David

AU - Murphy, Neil

AU - Rinaldi, Sabina

AU - Schmidt, Julie A

AU - Stepien, Magdalena

AU - Kaaks, Rudolf

AU - Kühn, Tilman

AU - Boeing, Heiner

AU - Iqbal, Khalid

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Panico, Salvatore

AU - Peeters, Petra H

AU - Bueno-de-Mesquita, Bas

AU - Ardanaz, Eva

AU - Lujan-Barroso, Leila

AU - Quirós, J Ramón

AU - Huerta, José M

AU - Molina-Portillo, Elena

AU - Dorronsoro, Miren

AU - Tsilidis, Konstantinos K

AU - Riboli, Elio

AU - Rostgaard-Hansen, Agnetha Linn

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Weiderpass, Elisabete

AU - Boutron-Ruault, Marie Christine

AU - Severi, Gianluca

AU - Trichopoulou, Antonia

AU - Karakatsani, Anna

AU - Kotanidou, Anastasia

AU - Håkansson, Anders

AU - Malm, Johan

AU - Weijenberg, Matty P

AU - Gunter, Marc J

AU - Jenab, Mazda

AU - Johansson, Mattias

AU - Travis, Ruth C

AU - Scalbert, Augustin

AU - Ferrari, Pietro

PY - 2018

Y1 - 2018

N2 - Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTMp180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption withmetabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.

AB - Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTMp180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption withmetabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.

KW - Acylcarnitines

KW - Alcohol

KW - Amino acids

KW - Lipid metabolites

KW - Targeted metabolomics

U2 - 10.3390/nu10050654

DO - 10.3390/nu10050654

M3 - Journal article

C2 - 29789452

AN - SCOPUS:85047641243

SN - 2072-6643

VL - 10

JO - Nutrients

JF - Nutrients

IS - 5

M1 - 654

ER -