Cimetidin og kreatininclearance

Niels Vidiendal Olsen; S D Ladefoged; B F Feldt-Rasmussen; N Fogh-Andersen; O Munck

Cimetidin og kreatininclearance

Niels Vidiendal Olsen, S D Ladefoged, B F Feldt-Rasmussen, N Fogh-Andersen, O Munck

Eyepath Lab

1 Citationer (Scopus)

Abstract

Cimetidine lowers secretion of creatinine in the renal tubuli in healthy individuals and persons with chronic renal disease. The conditions in patients with renal transplants have hitherto been unknown. The renal clearance of endogenic creatinine (CKrea) was investigated prior to and after an intravenous bolus injektion of cimetidine (5 mg/kg) in nine patients with renal transplants. The rate of glomerular filtration (GFR) was determined by clearance investigation of 125I-thalamate (CTh). CKrea fell 29% from 65 ml/min (median) to 46 ml/min (p less than 0.01), whereas GFR remained unchanged. The fractionated creatinine clearance (CKrea/CTh) fell therefore from 1.43 (median) to 1.03 (p less than 0.01). It is concluded that cimetidine reduces creatinine secretion in patients with renal transplants and this should be borne in mind when the function of the graft is assessed solely with CKrea.

Bidragets oversatte titel	Cimetidine and creatinine clearance
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	151
Udgave nummer	35
Sider (fra-til)	2202-3
Antal sider	2
ISSN	0041-5782
Status	Udgivet - 28 aug. 1989

Emneord

Adult
Cimetidine
Creatinine
Glomerular Filtration Rate
Humans
Injections, Intravenous
Kidney Transplantation
Middle Aged

Citationsformater

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title = "Cimetidin og kreatininclearance",

abstract = "Cimetidine lowers secretion of creatinine in the renal tubuli in healthy individuals and persons with chronic renal disease. The conditions in patients with renal transplants have hitherto been unknown. The renal clearance of endogenic creatinine (CKrea) was investigated prior to and after an intravenous bolus injektion of cimetidine (5 mg/kg) in nine patients with renal transplants. The rate of glomerular filtration (GFR) was determined by clearance investigation of 125I-thalamate (CTh). CKrea fell 29% from 65 ml/min (median) to 46 ml/min (p less than 0.01), whereas GFR remained unchanged. The fractionated creatinine clearance (CKrea/CTh) fell therefore from 1.43 (median) to 1.03 (p less than 0.01). It is concluded that cimetidine reduces creatinine secretion in patients with renal transplants and this should be borne in mind when the function of the graft is assessed solely with CKrea.",

keywords = "Adult, Cimetidine, Creatinine, Glomerular Filtration Rate, Humans, Injections, Intravenous, Kidney Transplantation, Middle Aged",

author = "Olsen, {Niels Vidiendal} and Ladefoged, {S D} and Feldt-Rasmussen, {B F} and N Fogh-Andersen and O Munck",

year = "1989",

month = aug,

day = "28",

language = "Dansk",

volume = "151",

pages = "2202--3",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

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TY - JOUR

T1 - Cimetidin og kreatininclearance

AU - Olsen, Niels Vidiendal

AU - Ladefoged, S D

AU - Feldt-Rasmussen, B F

AU - Fogh-Andersen, N

AU - Munck, O

PY - 1989/8/28

Y1 - 1989/8/28

N2 - Cimetidine lowers secretion of creatinine in the renal tubuli in healthy individuals and persons with chronic renal disease. The conditions in patients with renal transplants have hitherto been unknown. The renal clearance of endogenic creatinine (CKrea) was investigated prior to and after an intravenous bolus injektion of cimetidine (5 mg/kg) in nine patients with renal transplants. The rate of glomerular filtration (GFR) was determined by clearance investigation of 125I-thalamate (CTh). CKrea fell 29% from 65 ml/min (median) to 46 ml/min (p less than 0.01), whereas GFR remained unchanged. The fractionated creatinine clearance (CKrea/CTh) fell therefore from 1.43 (median) to 1.03 (p less than 0.01). It is concluded that cimetidine reduces creatinine secretion in patients with renal transplants and this should be borne in mind when the function of the graft is assessed solely with CKrea.

AB - Cimetidine lowers secretion of creatinine in the renal tubuli in healthy individuals and persons with chronic renal disease. The conditions in patients with renal transplants have hitherto been unknown. The renal clearance of endogenic creatinine (CKrea) was investigated prior to and after an intravenous bolus injektion of cimetidine (5 mg/kg) in nine patients with renal transplants. The rate of glomerular filtration (GFR) was determined by clearance investigation of 125I-thalamate (CTh). CKrea fell 29% from 65 ml/min (median) to 46 ml/min (p less than 0.01), whereas GFR remained unchanged. The fractionated creatinine clearance (CKrea/CTh) fell therefore from 1.43 (median) to 1.03 (p less than 0.01). It is concluded that cimetidine reduces creatinine secretion in patients with renal transplants and this should be borne in mind when the function of the graft is assessed solely with CKrea.

KW - Adult

KW - Cimetidine

KW - Creatinine

KW - Glomerular Filtration Rate

KW - Humans

KW - Injections, Intravenous

KW - Kidney Transplantation

KW - Middle Aged

M3 - Tidsskriftartikel

C2 - 2675442

SN - 0041-5782

VL - 151

SP - 2202

EP - 2203

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 35

ER -

Cimetidin og kreatininclearance

Abstract

Emneord

Fingeraftryk

Citationsformater