Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case–control studies

TY - JOUR

T1 - Cigarette smoking and risk of ovarian cancer

T2 - a pooled analysis of 21 case–control studies

AU - Faber, Mette T

AU - Kjær, Susanne K

AU - Dehlendorff, Christian

AU - Chang-Claude, Jenny

AU - Andersen, Klaus Kaae

AU - Høgdall, Estrid

AU - Webb, Penelope M

AU - Jordan, Susan J

AU - Rossing, Mary Anne

AU - Doherty, Jennifer A

AU - Lurie, Galina

AU - Thompson, Pamela J

AU - Carney, Michael E

AU - Goodman, Marc T

AU - Ness, Roberta B

AU - Modugno, Francesmary

AU - Edwards, Robert

AU - Bunker, Clareann H

AU - Goode, Ellen L

AU - Fridley, Brooke L

AU - Vierkant, Robert A

AU - Larson, Melissa C

AU - Schildkraut, Joellen

AU - Cramer, Daniel W

AU - Terry, Kathryn L

AU - Vitonis, Allison F

AU - Bandera, Elisa V

AU - Olson, Sara H

AU - King, Melony

AU - Chandran, Urmila

AU - Kiemeney, Lambertus A

AU - Massuger, Leon F A G

AU - van Altena, Anne M

AU - Vermeulen, Sita H

AU - Brinton, Louise

AU - Wentzensen, Nicolas

AU - Lissowska, Jolanta

AU - Yang, Hannah P

AU - Moysich, Kirsten B

AU - Odunsi, Kunle

AU - Kasza, Karin

AU - Odunsi-Akanji, Oluwatosin

AU - Song, Honglin

AU - Pharaoh, Paul

AU - Shah, Mitul

AU - Whittemore, Alice S

AU - McGuire, Valerie

AU - Sieh, Weiva

AU - Sutphen, Rebecca

AU - Menon, Usha

AU - Gayther, Simon A

AU - Ramus, Susan J

AU - Gentry-Maharaj, Aleksandra

AU - Pearce, Celeste Leigh

AU - Wu, Anna H

AU - Pike, Malcolm C

AU - Risch, Harvey A

AU - Jensen, Allan

AU - Cancer), Australian Cancer Study (Ovarian

PY - 2013/5

Y1 - 2013/5

N2 - Purpose The majority of previous studies have observed an increased risk of mucinous ovarian tumors associated with cigarette smoking, but the association with other histological types is unclear. In a large pooled analysis, we examined the risk of epithelial ovarian cancer associated with multiple measures of cigarette smoking with a focus on characterizing risks according to tumor behavior and histology. Methods We used data from 21 case-control studies of ovarian cancer (19,066 controls, 11,972 invasive and 2,752 borderline cases). Study-specific odds ratios (OR) and 95 % confidence intervals (CI) were obtained from logistic regression models and combined into a pooled odds ratio using a random effects model. Results Current cigarette smoking increased the risk of invasive mucinous (OR = 1.31; 95 % CI: 1.03-1.65) and borderline mucinous ovarian tumors (OR = 1.83; 95 % CI: 1.39-2.41), while former smoking increased the risk of borderline serous ovarian tumors (OR = 1.30; 95 % CI: 1.12-1.50). For these histological types, consistent dose- response associations were observed. No convincing associations between smoking and risk of invasive serous and endometrioid ovarian cancer were observed, while our results provided some evidence of a decreased risk of invasive clear cell ovarian cancer. Conclusions Our results revealed marked differences in the risk profiles of histological types of ovarian cancer with regard to cigarette smoking, although the magnitude of the observed associations was modest. Our findings, which may reflect different etiologies of the histological types, add to the fact that ovarian cancer is a heterogeneous disease.

AB - Purpose The majority of previous studies have observed an increased risk of mucinous ovarian tumors associated with cigarette smoking, but the association with other histological types is unclear. In a large pooled analysis, we examined the risk of epithelial ovarian cancer associated with multiple measures of cigarette smoking with a focus on characterizing risks according to tumor behavior and histology. Methods We used data from 21 case-control studies of ovarian cancer (19,066 controls, 11,972 invasive and 2,752 borderline cases). Study-specific odds ratios (OR) and 95 % confidence intervals (CI) were obtained from logistic regression models and combined into a pooled odds ratio using a random effects model. Results Current cigarette smoking increased the risk of invasive mucinous (OR = 1.31; 95 % CI: 1.03-1.65) and borderline mucinous ovarian tumors (OR = 1.83; 95 % CI: 1.39-2.41), while former smoking increased the risk of borderline serous ovarian tumors (OR = 1.30; 95 % CI: 1.12-1.50). For these histological types, consistent dose- response associations were observed. No convincing associations between smoking and risk of invasive serous and endometrioid ovarian cancer were observed, while our results provided some evidence of a decreased risk of invasive clear cell ovarian cancer. Conclusions Our results revealed marked differences in the risk profiles of histological types of ovarian cancer with regard to cigarette smoking, although the magnitude of the observed associations was modest. Our findings, which may reflect different etiologies of the histological types, add to the fact that ovarian cancer is a heterogeneous disease.

U2 - 10.1007/s10552-013-0174-4

DO - 10.1007/s10552-013-0174-4

M3 - Journal article

C2 - 23456270

SN - 0957-5243

VL - 24

SP - 989

EP - 1004

JO - Cancer Causes & Control

JF - Cancer Causes & Control

IS - 5

ER -