Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis

TY - JOUR

T1 - Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis

AU - Dalbøge, C S

AU - Hansen, C R

AU - Pressler, T

AU - Høiby, N

AU - Johansen, H K

N1 - Copyright © 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Background The clinical consequences of chronic Stenotrophomonas maltophilia infection in cystic fibrosis (CF) patient are still unclear. Method All patients treated in the Copenhagen CF centre (N=278) from 1 January 2008 to 31 December 2009 were included. Each patient chronically infected with S. maltophilia for at least 2years without any other chronic Gram-negative infection were matched to two non-infected CF controls. Results Twenty-one patients were chronically infected with S. maltophilia during the 2-year study period. Fifteen were infected for at least 2years. The patients in the S. maltophilia group had a steeper decline (-3.2%/year vs. -0.3%/year) in FEV1 compared to the non-infected CF controls (P=0.03). The rate of decline was the same as observed 3years before the patients became chronically infected. Discussions Chronic infection with S. maltophilia does not lead to a steeper decline in lung function when compared to the period before chronic infection.

AB - Background The clinical consequences of chronic Stenotrophomonas maltophilia infection in cystic fibrosis (CF) patient are still unclear. Method All patients treated in the Copenhagen CF centre (N=278) from 1 January 2008 to 31 December 2009 were included. Each patient chronically infected with S. maltophilia for at least 2years without any other chronic Gram-negative infection were matched to two non-infected CF controls. Results Twenty-one patients were chronically infected with S. maltophilia during the 2-year study period. Fifteen were infected for at least 2years. The patients in the S. maltophilia group had a steeper decline (-3.2%/year vs. -0.3%/year) in FEV1 compared to the non-infected CF controls (P=0.03). The rate of decline was the same as observed 3years before the patients became chronically infected. Discussions Chronic infection with S. maltophilia does not lead to a steeper decline in lung function when compared to the period before chronic infection.

U2 - 10.1016/j.jcf.2011.03.006

DO - 10.1016/j.jcf.2011.03.006

M3 - Journal article

C2 - 21463972

SN - 1569-1993

VL - 10

SP - 318

EP - 325

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - 5

ER -