Chromatin replication and epigenome maintenance

Constance Alabert; Anja Groth

doi:10.1038/nrm3288

Chromatin replication and epigenome maintenance

Constance Alabert, Anja Groth

277 Citationer (Scopus)

3315 Downloads (Pure)

Abstract

Stability and function of eukaryotic genomes are closely linked to chromatin structure and organization. During cell division the entire genome must be accurately replicated and the chromatin landscape reproduced on new DNA. Chromatin and nuclear structure influence where and when DNA replication initiates, whereas the replication process itself disrupts chromatin and challenges established patterns of genome regulation. Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking place throughout the cell cycle. If DNA synthesis is perturbed, cells can suffer loss of both genome and epigenome integrity with severe consequences for the organism.

Originalsprog	Engelsk
Tidsskrift	Nature Reviews. Molecular Cell Biology
Vol/bind	13
Udgave nummer	3
Sider (fra-til)	153-67
Antal sider	15
ISSN	1471-0072
DOI	https://doi.org/10.1038/nrm3288
Status	Udgivet - mar. 2012

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10.1038/nrm3288

NRM-10-193V3_ManuscriptAccepteret manuskript, 435 KB
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Citationsformater

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AB - Stability and function of eukaryotic genomes are closely linked to chromatin structure and organization. During cell division the entire genome must be accurately replicated and the chromatin landscape reproduced on new DNA. Chromatin and nuclear structure influence where and when DNA replication initiates, whereas the replication process itself disrupts chromatin and challenges established patterns of genome regulation. Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking place throughout the cell cycle. If DNA synthesis is perturbed, cells can suffer loss of both genome and epigenome integrity with severe consequences for the organism.

KW - Animals

KW - Cell Division

KW - Chromatin

KW - Chromatin Assembly and Disassembly

KW - DNA Replication

KW - Epigenesis, Genetic

KW - Epigenomics

KW - Genomic Instability

KW - Histones

KW - Humans

KW - Multiprotein Complexes

KW - Replication Origin

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DO - 10.1038/nrm3288

M3 - Review

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EP - 167

JO - Nature Reviews. Molecular Cell Biology

JF - Nature Reviews. Molecular Cell Biology

IS - 3

ER -

Chromatin replication and epigenome maintenance

Abstract

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