Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair

Nidhi Nair; Muhammad Shoaib; Claus Storgaard Sørensen

doi:10.3390/ijms18071486

Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair

Nidhi Nair, Muhammad Shoaib, Claus Storgaard Sørensen^*

^*Corresponding author af dette arbejde

42 Citationer (Scopus)

159 Downloads (Pure)

Abstract

Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage.

Originalsprog	Engelsk
Artikelnummer	1486
Tidsskrift	International Journal of Molecular Sciences
Vol/bind	18
Udgave nummer	7
Antal sider	21
ISSN	1661-6596
DOI	https://doi.org/10.3390/ijms18071486
Status	Udgivet - 10 jul. 2017

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10.3390/ijms18071486Licens: CC BY

Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA RepairForlagets udgivne version, 927 KBLicens: CC BY

Citationsformater

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abstract = "Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage.",

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AU - Nair, Nidhi

AU - Shoaib, Muhammad

AU - Sørensen, Claus Storgaard

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N2 - Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage.

AB - Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage.

KW - Chromatin

KW - DNA damage response

KW - Endogenous DNA damage

KW - Genome maintenance

U2 - 10.3390/ijms18071486

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M3 - Review

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Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair

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