Choroidal thickness in relation to birth parameters in 11- to 12-year-old children: the Copenhagen Child Cohort 2000 Eye Study

TY - JOUR

T1 - Choroidal thickness in relation to birth parameters in 11- to 12-year-old children

T2 - the Copenhagen Child Cohort 2000 Eye Study

AU - Li, Xiao Q

AU - Munkholm, Anja

AU - Larsen, Michael

AU - Munch, Inger C

AU - Copenhagen Child Cohort 2000 Study Group

N1 - Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.

PY - 2014/10/15

Y1 - 2014/10/15

N2 - PURPOSE. To examine choroidal thickness in a population-based child cohort in relation to birth parameters. METHODS. The Copenhagen Child Cohort 2000 Eye Study examined 1406 children aged 11 to 12 years using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), ocular biometry and measurement of height, weight, refraction, and self-reported pubertal development status. Birth parameters were obtained from the Danish Medical Birth Registry. RESULTS. The subfoveal choroid in low birth weight children (<2500 g, n ¼ 51, mean 324 6 76 lm) was thinner than in normal birth weight children (2500-4500 g, n ¼ 1194, mean 361 6 78 lm), the difference being 37 (CI95 60 to 15) lm, P ¼ 0.001 after adjusting for age, sex, height, Tanner stage by sex, axial length, anterior chamber depth, and spherical equivalent refractive error. The subfoveal choroid in high birth weight children (>4500 g, n ¼ 48, mean 351663 lm) was comparable with normal birth weight children, P ¼ 0.44. The subfoveal choroid was thinner in preterm children, however the difference was not significant (18 [37 to 2] lm, P ¼ 0.08). Small for gestation children had thinner subfoveal choroid (19 [37 to 1] lm, P ¼ 0.04) compared with appropriate for gestation children. Longer birth length was associated with a thicker subfoveal choroid (2 [1-4] lm/cm, P ¼ 0.005). Macular choroidal thickness at 16 extrafoveal locations was measured in a subset of children and found to have the same associations with birth weight as the subfoveal choroidal thickness. CONCLUSIONS. In 11-to 12-year-old children, thinner choroids were associated with lower birth weight, lower birth length, and being small for the gestational age.

AB - PURPOSE. To examine choroidal thickness in a population-based child cohort in relation to birth parameters. METHODS. The Copenhagen Child Cohort 2000 Eye Study examined 1406 children aged 11 to 12 years using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), ocular biometry and measurement of height, weight, refraction, and self-reported pubertal development status. Birth parameters were obtained from the Danish Medical Birth Registry. RESULTS. The subfoveal choroid in low birth weight children (<2500 g, n ¼ 51, mean 324 6 76 lm) was thinner than in normal birth weight children (2500-4500 g, n ¼ 1194, mean 361 6 78 lm), the difference being 37 (CI95 60 to 15) lm, P ¼ 0.001 after adjusting for age, sex, height, Tanner stage by sex, axial length, anterior chamber depth, and spherical equivalent refractive error. The subfoveal choroid in high birth weight children (>4500 g, n ¼ 48, mean 351663 lm) was comparable with normal birth weight children, P ¼ 0.44. The subfoveal choroid was thinner in preterm children, however the difference was not significant (18 [37 to 2] lm, P ¼ 0.08). Small for gestation children had thinner subfoveal choroid (19 [37 to 1] lm, P ¼ 0.04) compared with appropriate for gestation children. Longer birth length was associated with a thicker subfoveal choroid (2 [1-4] lm/cm, P ¼ 0.005). Macular choroidal thickness at 16 extrafoveal locations was measured in a subset of children and found to have the same associations with birth weight as the subfoveal choroidal thickness. CONCLUSIONS. In 11-to 12-year-old children, thinner choroids were associated with lower birth weight, lower birth length, and being small for the gestational age.

KW - Biometry

KW - Birth Weight

KW - Child

KW - Choroid

KW - Denmark

KW - Female

KW - Gestational Age

KW - Humans

KW - Infant, Low Birth Weight

KW - Infant, Small for Gestational Age

KW - Male

KW - Organ Size

KW - Registries

KW - Tomography, Optical Coherence

U2 - 10.1167/iovs.14-15016

DO - 10.1167/iovs.14-15016

M3 - Journal article

C2 - 25358736

SN - 0146-0404

VL - 56

SP - 617

EP - 624

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

ER -