Chimpanzee genomic diversity reveals ancient admixture with bonobos

Marc de Manuel; Martin Kuhlwilm; Peter Frandsen; Vitor C. Sousa; Tariq Desai; Javier Prado-Martinez; Jessica Hernandez-Rodriguez; Isabelle Dupanloup; Oscar Lao; Pille Hallast; Joshua M. Schmidt; José María Heredia-Genestar; Andrea Benazzo; Guido Barbujani; Benjamin M. Peter; Lukas F. K. Kuderna; Ferran Casals; Samuel Angedakin; Mimi Arandjelovic; Christophe Boesch; Hjalmar Kühl; Linda Vigilant; Kevin Langergraber; John Novembre; Marta Gut; Ivo Gut; Arcadi Navarro; Frands Carlsen; Aida M. Andrés; Hans Redlef Siegismund; Aylwyn Scally; Laurent Excoffier; Chris Tyler-Smith; Sergi Castellano; Yali Xue; Christina Hvilsom; Tomas Marques-Bonet

doi:10.1126/science.aag2602

Chimpanzee genomic diversity reveals ancient admixture with bonobos

Marc de Manuel, Martin Kuhlwilm, Peter Frandsen, Vitor C. Sousa, Tariq Desai, Javier Prado-Martinez, Jessica Hernandez-Rodriguez, Isabelle Dupanloup, Oscar Lao, Pille Hallast, Joshua M. Schmidt, José María Heredia-Genestar, Andrea Benazzo, Guido Barbujani, Benjamin M. Peter, Lukas F. K. Kuderna, Ferran Casals, Samuel Angedakin, Mimi Arandjelovic, Christophe BoeschHjalmar Kühl, Linda Vigilant, Kevin Langergraber, John Novembre, Marta Gut, Ivo Gut, Arcadi Navarro, Frands Carlsen, Aida M. Andrés, Hans Redlef Siegismund, Aylwyn Scally, Laurent Excoffier, Chris Tyler-Smith, Sergi Castellano, Yali Xue, Christina Hvilsom, Tomas Marques-Bonet

Bioinformatik og RNA Biologi

106 Citationer (Scopus)

Abstract

Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.

Originalsprog	Engelsk
Tidsskrift	Science
Vol/bind	354
Udgave nummer	6311
Sider (fra-til)	477-481
Antal sider	5
ISSN	0036-8075
DOI	https://doi.org/10.1126/science.aag2602
Status	Udgivet - 28 okt. 2016

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de Manuel, M., Kuhlwilm, M., Frandsen, P., Sousa, V. C., Desai, T., Prado-Martinez, J., Hernandez-Rodriguez, J., Dupanloup, I., Lao, O., Hallast, P., Schmidt, J. M., Heredia-Genestar, J. M., Benazzo, A., Barbujani, G., Peter, B. M., Kuderna, L. F. K., Casals, F., Angedakin, S., Arandjelovic, M., ... Marques-Bonet, T. (2016). Chimpanzee genomic diversity reveals ancient admixture with bonobos. Science, 354(6311), 477-481. https://doi.org/10.1126/science.aag2602

de Manuel, M, Kuhlwilm, M, Frandsen, P, Sousa, VC, Desai, T, Prado-Martinez, J, Hernandez-Rodriguez, J, Dupanloup, I, Lao, O, Hallast, P, Schmidt, JM, Heredia-Genestar, JM, Benazzo, A, Barbujani, G, Peter, BM, Kuderna, LFK, Casals, F, Angedakin, S, Arandjelovic, M, Boesch, C, Kühl, H, Vigilant, L, Langergraber, K, Novembre, J, Gut, M, Gut, I, Navarro, A, Carlsen, F, Andrés, AM, Siegismund, HR, Scally, A, Excoffier, L, Tyler-Smith, C, Castellano, S, Xue, Y, Hvilsom, C & Marques-Bonet, T 2016, 'Chimpanzee genomic diversity reveals ancient admixture with bonobos', Science, bind 354, nr. 6311, s. 477-481. https://doi.org/10.1126/science.aag2602

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title = "Chimpanzee genomic diversity reveals ancient admixture with bonobos",

abstract = "Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.",

author = "{de Manuel}, Marc and Martin Kuhlwilm and Peter Frandsen and Sousa, {Vitor C.} and Tariq Desai and Javier Prado-Martinez and Jessica Hernandez-Rodriguez and Isabelle Dupanloup and Oscar Lao and Pille Hallast and Schmidt, {Joshua M.} and Heredia-Genestar, {Jos{\'e} Mar{\'i}a} and Andrea Benazzo and Guido Barbujani and Peter, {Benjamin M.} and Kuderna, {Lukas F. K.} and Ferran Casals and Samuel Angedakin and Mimi Arandjelovic and Christophe Boesch and Hjalmar K{\"u}hl and Linda Vigilant and Kevin Langergraber and John Novembre and Marta Gut and Ivo Gut and Arcadi Navarro and Frands Carlsen and Andr{\'e}s, {Aida M.} and Siegismund, {Hans Redlef} and Aylwyn Scally and Laurent Excoffier and Chris Tyler-Smith and Sergi Castellano and Yali Xue and Christina Hvilsom and Tomas Marques-Bonet",

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AU - de Manuel, Marc

AU - Kuhlwilm, Martin

AU - Frandsen, Peter

AU - Sousa, Vitor C.

AU - Desai, Tariq

AU - Prado-Martinez, Javier

AU - Hernandez-Rodriguez, Jessica

AU - Dupanloup, Isabelle

AU - Lao, Oscar

AU - Hallast, Pille

AU - Schmidt, Joshua M.

AU - Heredia-Genestar, José María

AU - Benazzo, Andrea

AU - Barbujani, Guido

AU - Peter, Benjamin M.

AU - Kuderna, Lukas F. K.

AU - Casals, Ferran

AU - Angedakin, Samuel

AU - Arandjelovic, Mimi

AU - Boesch, Christophe

AU - Kühl, Hjalmar

AU - Vigilant, Linda

AU - Langergraber, Kevin

AU - Novembre, John

AU - Gut, Marta

AU - Gut, Ivo

AU - Navarro, Arcadi

AU - Carlsen, Frands

AU - Andrés, Aida M.

AU - Siegismund, Hans Redlef

AU - Scally, Aylwyn

AU - Excoffier, Laurent

AU - Tyler-Smith, Chris

AU - Castellano, Sergi

AU - Xue, Yali

AU - Hvilsom, Christina

AU - Marques-Bonet, Tomas

PY - 2016/10/28

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N2 - Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.

AB - Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.

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SP - 477

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JF - Science

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ER -

Chimpanzee genomic diversity reveals ancient admixture with bonobos

Abstract

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