Chemoprevention with Acetylsalicylic Acid, Vitamin D and Calcium Reduces Risk of Carcinogen-induced Lung Tumors

Hans-Christian Pommergaard; Jakob Burcharth; J Rosenberg; Hans Raskov

Chemoprevention with Acetylsalicylic Acid, Vitamin D and Calcium Reduces Risk of Carcinogen-induced Lung Tumors

Hans-Christian Pommergaard, Jakob Burcharth, J Rosenberg, Hans Raskov

Institut for Klinisk Medicin

11 Citationer (Scopus)

Abstract

Background/Aim: Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor. Materials and Methods: A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)₂-vitamin D ₃ and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks. Results: The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed. Conclusion: The chemoprevention diet had a protective effect against tumor development in the mouse lungs.

Originalsprog	Engelsk
Tidsskrift	Anticancer Research
Vol/bind	33
Udgave nummer	11
Sider (fra-til)	4767-4770
Antal sider	4
ISSN	0250-7005
Status	Udgivet - nov. 2013

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http://www.ncbi.nlm.nih.gov/pubmed/24222111

Citationsformater

@article{f5062d3d3a5343a69d3ac037ea92a329,

title = "Chemoprevention with Acetylsalicylic Acid, Vitamin D and Calcium Reduces Risk of Carcinogen-induced Lung Tumors",

abstract = "Background/Aim: Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor. Materials and Methods: A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D 3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks. Results: The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed. Conclusion: The chemoprevention diet had a protective effect against tumor development in the mouse lungs.",

author = "Hans-Christian Pommergaard and Jakob Burcharth and J Rosenberg and Hans Raskov",

year = "2013",

month = nov,

language = "English",

volume = "33",

pages = "4767--4770",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "11",

}

TY - JOUR

T1 - Chemoprevention with Acetylsalicylic Acid, Vitamin D and Calcium Reduces Risk of Carcinogen-induced Lung Tumors

AU - Pommergaard, Hans-Christian

AU - Burcharth, Jakob

AU - Rosenberg, J

AU - Raskov, Hans

PY - 2013/11

Y1 - 2013/11

N2 - Background/Aim: Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor. Materials and Methods: A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D 3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks. Results: The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed. Conclusion: The chemoprevention diet had a protective effect against tumor development in the mouse lungs.

AB - Background/Aim: Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor. Materials and Methods: A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D 3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks. Results: The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed. Conclusion: The chemoprevention diet had a protective effect against tumor development in the mouse lungs.

M3 - Journal article

SN - 0250-7005

VL - 33

SP - 4767

EP - 4770

JO - Anticancer Research

JF - Anticancer Research

IS - 11

ER -

Chemoprevention with Acetylsalicylic Acid, Vitamin D and Calcium Reduces Risk of Carcinogen-induced Lung Tumors

Abstract

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