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Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors
Haigen Fu, J. Zhang, P.G. Tepper,
Lennart Bunch
,
Anders A. Jensen
, G.J. Poelarends
10
Citationer (Scopus)
83
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Keyphrases
Excitatory Amino Acid Transporter
100%
Aspartate
100%
Chemoenzymatic Synthesis
100%
Pharmacological Characterization
100%
Transporter Inhibitor
100%
EAAT1
100%
IC50 Value
60%
Non-selective
40%
EAAT2
20%
Hetero
20%
Glutamatergic Neurotransmission
20%
EAAT3
20%
Pharmacological Properties
20%
Compound 9
20%
Compound 8
20%
Selective Inhibitor
20%
Inhibitory Activity
20%
Chemistry
Aspartate
100%
Excitatory Amino Acid
100%
Aspartic Acid
100%
IC50
60%
Pharmacological Property
20%
Pharmacology, Toxicology and Pharmaceutical Science
Excitatory Amino Acid Transporter
100%
Aspartic Acid
100%
IC50
60%