TY - JOUR
T1 - Chemistry and biology of terpene trilactones from Ginkgo biloba
AU - Strømgaard, Kristian
AU - Nakanishi, Koji
PY - 2004/3/19
Y1 - 2004/3/19
N2 - Ginkgo biloba, the ginkgo tree, is the oldest living tree, with a long history of use in traditional Chinese medicine. In recent years, the leaf extracts have been widely sold as phytomedicine in Europe and as a dietary supplement worldwide. Effects of Ginkgo biloba extracts have been postulated to include improvement of memory, increased blood circulation, as well as beneficial effects to sufferers of Alzheimer's disease. The most unique components of the extracts are the terpene trilactones, that is, ginkgolides and bilobalide. These structurally complex molecules have been attractive targets for total synthesis. Terpene trilactones are believed to be partly responsible for the neuromodulatory properties of Ginkgo biloba extracts, and several biological effects of the terpene trilactones have been discovered in recent years, making them attractive pharmacological tools that could provide insight into the effects of Ginkgo biloba extracts.
AB - Ginkgo biloba, the ginkgo tree, is the oldest living tree, with a long history of use in traditional Chinese medicine. In recent years, the leaf extracts have been widely sold as phytomedicine in Europe and as a dietary supplement worldwide. Effects of Ginkgo biloba extracts have been postulated to include improvement of memory, increased blood circulation, as well as beneficial effects to sufferers of Alzheimer's disease. The most unique components of the extracts are the terpene trilactones, that is, ginkgolides and bilobalide. These structurally complex molecules have been attractive targets for total synthesis. Terpene trilactones are believed to be partly responsible for the neuromodulatory properties of Ginkgo biloba extracts, and several biological effects of the terpene trilactones have been discovered in recent years, making them attractive pharmacological tools that could provide insight into the effects of Ginkgo biloba extracts.
KW - Biology
KW - Chemical Phenomena
KW - Chemistry
KW - Ginkgo biloba
KW - Molecular Conformation
KW - Terpenes
U2 - 10.1002/anie.200300601
DO - 10.1002/anie.200300601
M3 - Journal article
C2 - 15038029
SN - 1433-7851
VL - 43
SP - 1640
EP - 1658
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
IS - 13
ER -