Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

Birgitte Romme Nielsen; Rikke Ratzer; Lars Börnsen; Marina Rode von Essen; Jeppe Romme Christensen; Finn Sellebjerg

doi:10.1016/j.jneuroim.2017.06.001

Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

Birgitte Romme Nielsen^*, Rikke Ratzer, Lars Börnsen, Marina Rode von Essen, Jeppe Romme Christensen, Finn Sellebjerg

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

9 Citationer (Scopus)

Abstract

We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4⁺ and CD8⁺ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26⁺ CD28⁺ CD4⁺ TEMRA T cells were increased in all subtypes of MS, and CD26⁺ CD28⁺ CD8⁺ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d⁺ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

Originalsprog	Engelsk
Tidsskrift	Journal of Neuroimmunology
Vol/bind	310
Sider (fra-til)	17-25
Antal sider	9
ISSN	0165-5728
DOI	https://doi.org/10.1016/j.jneuroim.2017.06.001
Status	Udgivet - 2017

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10.1016/j.jneuroim.2017.06.001

Citationsformater

@article{38677f4d9bb24391876a9f71dcaa2bfd,

title = "Characterization of na{\"i}ve, memory and effector T cells in progressive multiple sclerosis",

abstract = "We characterized na{\"i}ve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.",

keywords = "CD26, CD49, Memory, Natalizumab, Progressive MS, T cells",

author = "Nielsen, {Birgitte Romme} and Rikke Ratzer and Lars B{\"o}rnsen and {von Essen}, {Marina Rode} and Christensen, {Jeppe Romme} and Finn Sellebjerg",

year = "2017",

doi = "10.1016/j.jneuroim.2017.06.001",

language = "English",

volume = "310",

pages = "17--25",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

AU - Nielsen, Birgitte Romme

AU - Ratzer, Rikke

AU - Börnsen, Lars

AU - von Essen, Marina Rode

AU - Christensen, Jeppe Romme

AU - Sellebjerg, Finn

PY - 2017

Y1 - 2017

N2 - We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

AB - We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

KW - CD26

KW - CD49

KW - Memory

KW - Natalizumab

KW - Progressive MS

KW - T cells

U2 - 10.1016/j.jneuroim.2017.06.001

DO - 10.1016/j.jneuroim.2017.06.001

M3 - Journal article

C2 - 28778440

AN - SCOPUS:85020812830

SN - 0165-5728

VL - 310

SP - 17

EP - 25

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

Abstract

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