Characterisation of non-P-glycoprotein multidrug-resistant Ehrlich ascites tumour cells selected for resistance to mitoxantrone

Medicin og biovidenskab

• Ehrlich Tumor Carcinoma 93%
• Mitoxantrone 88%
• Glycoproteins 58%
• Adenosine Triphosphatases 26%
• Microsomes 23%
• Daunorubicin 19%
• ATP Binding Cassette Transporter, Subfamily B, Member 1 17%
• Verapamil 11%
• Multidrug Resistance-Associated Proteins 7%
• Vanadates 6%
• Messenger RNA 5%
• Vincristine 5%
• Etoposide 5%
• Tumor Cell Line 5%
• Cyclosporine 4%
• Carrier Proteins 4%
• Western Blotting 3%
• Cell Line 3%
• Pharmaceutical Preparations 2%
• Proteins 1%

Kemiske forbindelser

• Mitoxantrone 100%
• Resistance 42%
• Daunorubicin 22%
• Verapamil 13%
• Vincristine 7%
• Cyclosporin A 7%
• Etoposide 7%
• Protein 6%
• Sensitization 5%
• Drug 2%
• Reduction 2%