Abstract
Background: Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antigen (CEA) levels in patients with stage III colon cancer. Patients and Methods: Thirty patients who had been curatively resected for stage III colon cancer were included. The patients received 10-12 cycles of modified FOLFOX6 regimen. Blood samples were collected before and after the first and the second cycle and three months later. Results: No significant change could be detected in CEA levels while TIMP-1 raised significantly after the second cycle but returned to normal 3 months later. Conclusion: Plasma CEA levels are stable during adjuvant chemotherapy while the plasma level of TIMP-1 might be directly affected by chemotherapy represented by a transient rise about 2 weeks following the initiation of treatment.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Anticancer Research |
| Vol/bind | 30 |
| Udgave nummer | 1 |
| Sider (fra-til) | 233-237 |
| Antal sider | 5 |
| ISSN | 0250-7005 |
| Status | Udgivet - jan. 2010 |
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