Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study

N. Aslund; S.F. Thomsen; E. Molgaard; H. Nolte; V. Backer

Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study

N. Aslund, S.F. Thomsen, E. Molgaard, H. Nolte, V. Backer

6 Citationer (Scopus)

Abstract

Background: Our knowledge about longtudinal predictors of atopy is limited. Objectives: To describe changes in skin test reactivity during a 3-year period in a sample of adolescents and adults with atopic disease and to identify factors of importance for these changes. Methods: From a sample of 1, 186 candidates, ranging in age from 14 to 44 years, who in a screening questionnaire reported symptoms suggestive of respiratory allergic disease, 344 individuals with a positive skin prick test (SPT) result concomitantly with asthma and/or rhinitis were clinically studied on 2 occasions, 3 years apart. Results: In total, 134 (39% of the Study population) had a different SPT result at follow-up compared with baseline, based on a diagnostic criterion of 3 min for a positive test result 77 (22%) developed de novo sensitizations to I or more allergens, 45 (13%) had remission of 1 or more sensitizations, and 12 (4%) both gained and lost sensitizations. Female sex (odds ratio = 1.90 [1.02-3.57] P =.04) significantly predicted incidence of 1 or more sensitizations. Conclusions: Four of 10 adults with atopic disease will have changes in SPT status during a 3-year period, and most will gain new sensitizations. Women with atopic disease are at increased risk of developing new sensitizations compared with men
Udgivelsesdato: 2008/11

Originalsprog	Engelsk
Tidsskrift	Annals of Allergy, Asthma, & Immunology
Vol/bind	101
Udgave nummer	5
Sider (fra-til)	524-528
Antal sider	4
ISSN	1081-1206
Status	Udgivet - 2008

Citationsformater

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title = "Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study",

abstract = "Background: Our knowledge about longtudinal predictors of atopy is limited. Objectives: To describe changes in skin test reactivity during a 3-year period in a sample of adolescents and adults with atopic disease and to identify factors of importance for these changes. Methods: From a sample of 1, 186 candidates, ranging in age from 14 to 44 years, who in a screening questionnaire reported symptoms suggestive of respiratory allergic disease, 344 individuals with a positive skin prick test (SPT) result concomitantly with asthma and/or rhinitis were clinically studied on 2 occasions, 3 years apart. Results: In total, 134 (39% of the Study population) had a different SPT result at follow-up compared with baseline, based on a diagnostic criterion of 3 min for a positive test result 77 (22%) developed de novo sensitizations to I or more allergens, 45 (13%) had remission of 1 or more sensitizations, and 12 (4%) both gained and lost sensitizations. Female sex (odds ratio = 1.90 [1.02-3.57] P =.04) significantly predicted incidence of 1 or more sensitizations. Conclusions: Four of 10 adults with atopic disease will have changes in SPT status during a 3-year period, and most will gain new sensitizations. Women with atopic disease are at increased risk of developing new sensitizations compared with men Udgivelsesdato: 2008/11",

author = "N. Aslund and S.F. Thomsen and E. Molgaard and H. Nolte and V. Backer",

note = "Times Cited: 0ArticleEnglishThomsen, S. FBispebjerg Hosp, Dept Resp Med, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, DenmarkCited References Count: 25369WYAMER COLL ALLERGY ASTHMA IMMUNOLOGY85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USAARLINGTON HTS",

year = "2008",

language = "English",

volume = "101",

pages = "524--528",

journal = "Annals of Allergy, Asthma and Immunology",

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TY - JOUR

T1 - Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study

AU - Aslund, N.

AU - Thomsen, S.F.

AU - Molgaard, E.

AU - Nolte, H.

AU - Backer, V.

N1 - Times Cited: 0ArticleEnglishThomsen, S. FBispebjerg Hosp, Dept Resp Med, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, DenmarkCited References Count: 25369WYAMER COLL ALLERGY ASTHMA IMMUNOLOGY85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USAARLINGTON HTS

PY - 2008

Y1 - 2008

N2 - Background: Our knowledge about longtudinal predictors of atopy is limited. Objectives: To describe changes in skin test reactivity during a 3-year period in a sample of adolescents and adults with atopic disease and to identify factors of importance for these changes. Methods: From a sample of 1, 186 candidates, ranging in age from 14 to 44 years, who in a screening questionnaire reported symptoms suggestive of respiratory allergic disease, 344 individuals with a positive skin prick test (SPT) result concomitantly with asthma and/or rhinitis were clinically studied on 2 occasions, 3 years apart. Results: In total, 134 (39% of the Study population) had a different SPT result at follow-up compared with baseline, based on a diagnostic criterion of 3 min for a positive test result 77 (22%) developed de novo sensitizations to I or more allergens, 45 (13%) had remission of 1 or more sensitizations, and 12 (4%) both gained and lost sensitizations. Female sex (odds ratio = 1.90 [1.02-3.57] P =.04) significantly predicted incidence of 1 or more sensitizations. Conclusions: Four of 10 adults with atopic disease will have changes in SPT status during a 3-year period, and most will gain new sensitizations. Women with atopic disease are at increased risk of developing new sensitizations compared with men Udgivelsesdato: 2008/11

AB - Background: Our knowledge about longtudinal predictors of atopy is limited. Objectives: To describe changes in skin test reactivity during a 3-year period in a sample of adolescents and adults with atopic disease and to identify factors of importance for these changes. Methods: From a sample of 1, 186 candidates, ranging in age from 14 to 44 years, who in a screening questionnaire reported symptoms suggestive of respiratory allergic disease, 344 individuals with a positive skin prick test (SPT) result concomitantly with asthma and/or rhinitis were clinically studied on 2 occasions, 3 years apart. Results: In total, 134 (39% of the Study population) had a different SPT result at follow-up compared with baseline, based on a diagnostic criterion of 3 min for a positive test result 77 (22%) developed de novo sensitizations to I or more allergens, 45 (13%) had remission of 1 or more sensitizations, and 12 (4%) both gained and lost sensitizations. Female sex (odds ratio = 1.90 [1.02-3.57] P =.04) significantly predicted incidence of 1 or more sensitizations. Conclusions: Four of 10 adults with atopic disease will have changes in SPT status during a 3-year period, and most will gain new sensitizations. Women with atopic disease are at increased risk of developing new sensitizations compared with men Udgivelsesdato: 2008/11

M3 - Journal article

SN - 1081-1206

VL - 101

SP - 524

EP - 528

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

IS - 5

ER -