Changes in plasma TIMP-1 levels after resection for primary colorectal cancer

C. Frederiksen; A.F. Lomholt; G.J. Davis; B.L. Dowell; M.A. Blankenstein; I.J. Christensen; Nils Brünner; H.J. Nielsen

Changes in plasma TIMP-1 levels after resection for primary colorectal cancer

C. Frederiksen, A.F. Lomholt, G.J. Davis, B.L. Dowell, M.A. Blankenstein, I.J. Christensen, Nils Brünner, H.J. Nielsen

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Abstract

BACKGROUND: Increased plasma levels of tissue inhibitor of metalloproteinases (TIMP-1) are associated with poor outcome in colorectal cancer (CRC), however postoperative changes in plasma TIMP-1 levels after resections for CRC have not been thoroughly evaluated. MATERIALS AND METHODS: Plasma samples were collected from 45 patients with primary CRC, preoperatively, 2 hours after surgery, and at days 1, 2, 7, 28, 45, 60, 75 and 90 after surgery. TIMP-1 and CEA levels were determined using the ARCHITECT Immunoanalyzer. RESULTS: Postoperatively, the mean (geometric) TIMP-1 level increased and had a maximum level at day 1 (p < 0.0001). The mean TIMP-1 level then declined to a level at day 90 similar to the mean preoperative level. CONCLUSION: A mean decline in plasma TIMP-1 levels was not observed within 90 days. However, individual significant reductions of plasma TIMP-1 levels did occur within 28-60 days postoperatively.

Originalsprog	Engelsk
Tidsskrift	Anticancer Research
Vol/bind	29
Udgave nummer	1
Sider (fra-til)	75-82
Antal sider	8
ISSN	0250-7005
Status	Udgivet - 2009

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Citationsformater

@article{f1c47770208811df8ed1000ea68e967b,

title = "Changes in plasma TIMP-1 levels after resection for primary colorectal cancer",

abstract = "BACKGROUND: Increased plasma levels of tissue inhibitor of metalloproteinases (TIMP-1) are associated with poor outcome in colorectal cancer (CRC), however postoperative changes in plasma TIMP-1 levels after resections for CRC have not been thoroughly evaluated. MATERIALS AND METHODS: Plasma samples were collected from 45 patients with primary CRC, preoperatively, 2 hours after surgery, and at days 1, 2, 7, 28, 45, 60, 75 and 90 after surgery. TIMP-1 and CEA levels were determined using the ARCHITECT Immunoanalyzer. RESULTS: Postoperatively, the mean (geometric) TIMP-1 level increased and had a maximum level at day 1 (p < 0.0001). The mean TIMP-1 level then declined to a level at day 90 similar to the mean preoperative level. CONCLUSION: A mean decline in plasma TIMP-1 levels was not observed within 90 days. However, individual significant reductions of plasma TIMP-1 levels did occur within 28-60 days postoperatively.",

author = "C. Frederiksen and A.F. Lomholt and G.J. Davis and B.L. Dowell and M.A. Blankenstein and I.J. Christensen and Nils Br{\"u}nner and H.J. Nielsen",

note = "Keywords: Adult; Aged; Aged, 80 and over; Carcinoembryonic Antigen; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Staging; Tissue Inhibitor of Metalloproteinase-1",

year = "2009",

language = "English",

volume = "29",

pages = "75--82",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "1",

}

TY - JOUR

T1 - Changes in plasma TIMP-1 levels after resection for primary colorectal cancer

AU - Frederiksen, C.

AU - Lomholt, A.F.

AU - Davis, G.J.

AU - Dowell, B.L.

AU - Blankenstein, M.A.

AU - Christensen, I.J.

AU - Brünner, Nils

AU - Nielsen, H.J.

N1 - Keywords: Adult; Aged; Aged, 80 and over; Carcinoembryonic Antigen; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Staging; Tissue Inhibitor of Metalloproteinase-1

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Increased plasma levels of tissue inhibitor of metalloproteinases (TIMP-1) are associated with poor outcome in colorectal cancer (CRC), however postoperative changes in plasma TIMP-1 levels after resections for CRC have not been thoroughly evaluated. MATERIALS AND METHODS: Plasma samples were collected from 45 patients with primary CRC, preoperatively, 2 hours after surgery, and at days 1, 2, 7, 28, 45, 60, 75 and 90 after surgery. TIMP-1 and CEA levels were determined using the ARCHITECT Immunoanalyzer. RESULTS: Postoperatively, the mean (geometric) TIMP-1 level increased and had a maximum level at day 1 (p < 0.0001). The mean TIMP-1 level then declined to a level at day 90 similar to the mean preoperative level. CONCLUSION: A mean decline in plasma TIMP-1 levels was not observed within 90 days. However, individual significant reductions of plasma TIMP-1 levels did occur within 28-60 days postoperatively.

AB - BACKGROUND: Increased plasma levels of tissue inhibitor of metalloproteinases (TIMP-1) are associated with poor outcome in colorectal cancer (CRC), however postoperative changes in plasma TIMP-1 levels after resections for CRC have not been thoroughly evaluated. MATERIALS AND METHODS: Plasma samples were collected from 45 patients with primary CRC, preoperatively, 2 hours after surgery, and at days 1, 2, 7, 28, 45, 60, 75 and 90 after surgery. TIMP-1 and CEA levels were determined using the ARCHITECT Immunoanalyzer. RESULTS: Postoperatively, the mean (geometric) TIMP-1 level increased and had a maximum level at day 1 (p < 0.0001). The mean TIMP-1 level then declined to a level at day 90 similar to the mean preoperative level. CONCLUSION: A mean decline in plasma TIMP-1 levels was not observed within 90 days. However, individual significant reductions of plasma TIMP-1 levels did occur within 28-60 days postoperatively.

M3 - Journal article

C2 - 19331135

SN - 0250-7005

VL - 29

SP - 75

EP - 82

JO - Anticancer Research

JF - Anticancer Research

IS - 1

ER -

Changes in plasma TIMP-1 levels after resection for primary colorectal cancer

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