Changes in interstitial K+ and pH during exercise: implications for blood flow regulation.

Carsten Juel

doi:10.1139/h07-065

Changes in interstitial K+ and pH during exercise: implications for blood flow regulation.

Carsten Juel

Molecular Integrative Physiology

14 Citationer (Scopus)

Abstract

The analysis of blood samples has clearly demonstrated that exercise is associated with the release of K+ and H+ from muscle. However, blood samples give only incomplete information about the ion changes in the muscle interstitium. Interstitial changes in ion composition may affect the transport properties of the sarcolemmal membrane, may affect fibre excitability and induce fatigue, and may affect sensory nerve endings. Therefore, to better understand muscle function, it is important to quantify the exercise-induced interstitial ion changes. Both interstitial K+ and H+ changes have been quantified with the microdialysis technique. Interstitial K+ accumulation is dependent on the intensity and duration of muscle activity and may reach 10 mmol/L during intense exercise, and the concentration in T-tubules may be even higher. Thus, interstitial K+ can reach a level that affects fibre excitability and the development of fatigue. It has also been demonstrated with microdialysis that the interstitial decrease in pH during muscle activity is larger than the reduction in blood pH. Ion changes in the interstitium may affect blood flow directly or indirectly. Infusion of K+ into the femoral artery in humans has demonstrated that blood flow is affected by changes in K+ as low as 0.1 mmol/L. The vasodilatory effect of K+ can be inhibited with simultaneous barium infusion, indicating that inward rectifier potassium (Kir)channels are involved. Acidosis has a direct effect on blood flow and an indirect effect, mediated by changes in other vasoactive compounds.
Udgivelsesdato: 2007-Oct

Originalsprog	Engelsk
Tidsskrift	Applied Physiology, Nutrition and Metabolism
Vol/bind	32
Udgave nummer	5
Sider (fra-til)	846-51
Antal sider	5
ISSN	1715-5312
DOI	https://doi.org/10.1139/h07-065
Status	Udgivet - 2007

Adgang til dokumentet

10.1139/h07-065

Citationsformater

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title = "Changes in interstitial K+ and pH during exercise: implications for blood flow regulation.",

abstract = "The analysis of blood samples has clearly demonstrated that exercise is associated with the release of K+ and H+ from muscle. However, blood samples give only incomplete information about the ion changes in the muscle interstitium. Interstitial changes in ion composition may affect the transport properties of the sarcolemmal membrane, may affect fibre excitability and induce fatigue, and may affect sensory nerve endings. Therefore, to better understand muscle function, it is important to quantify the exercise-induced interstitial ion changes. Both interstitial K+ and H+ changes have been quantified with the microdialysis technique. Interstitial K+ accumulation is dependent on the intensity and duration of muscle activity and may reach 10 mmol/L during intense exercise, and the concentration in T-tubules may be even higher. Thus, interstitial K+ can reach a level that affects fibre excitability and the development of fatigue. It has also been demonstrated with microdialysis that the interstitial decrease in pH during muscle activity is larger than the reduction in blood pH. Ion changes in the interstitium may affect blood flow directly or indirectly. Infusion of K+ into the femoral artery in humans has demonstrated that blood flow is affected by changes in K+ as low as 0.1 mmol/L. The vasodilatory effect of K+ can be inhibited with simultaneous barium infusion, indicating that inward rectifier potassium (Kir)channels are involved. Acidosis has a direct effect on blood flow and an indirect effect, mediated by changes in other vasoactive compounds. Udgivelsesdato: 2007-Oct",

author = "Carsten Juel",

note = "Keywords: Animals; Blood Flow Velocity; Exercise; Humans; Hydrogen-Ion Concentration; Muscle, Skeletal; Potassium",

year = "2007",

doi = "10.1139/h07-065",

language = "English",

volume = "32",

pages = "846--51",

journal = "Applied Physiology, Nutrition and Metabolism",

issn = "1715-5312",

publisher = "Canadian Science Publishing",

number = "5",

}

TY - JOUR

T1 - Changes in interstitial K+ and pH during exercise: implications for blood flow regulation.

AU - Juel, Carsten

N1 - Keywords: Animals; Blood Flow Velocity; Exercise; Humans; Hydrogen-Ion Concentration; Muscle, Skeletal; Potassium

PY - 2007

Y1 - 2007

N2 - The analysis of blood samples has clearly demonstrated that exercise is associated with the release of K+ and H+ from muscle. However, blood samples give only incomplete information about the ion changes in the muscle interstitium. Interstitial changes in ion composition may affect the transport properties of the sarcolemmal membrane, may affect fibre excitability and induce fatigue, and may affect sensory nerve endings. Therefore, to better understand muscle function, it is important to quantify the exercise-induced interstitial ion changes. Both interstitial K+ and H+ changes have been quantified with the microdialysis technique. Interstitial K+ accumulation is dependent on the intensity and duration of muscle activity and may reach 10 mmol/L during intense exercise, and the concentration in T-tubules may be even higher. Thus, interstitial K+ can reach a level that affects fibre excitability and the development of fatigue. It has also been demonstrated with microdialysis that the interstitial decrease in pH during muscle activity is larger than the reduction in blood pH. Ion changes in the interstitium may affect blood flow directly or indirectly. Infusion of K+ into the femoral artery in humans has demonstrated that blood flow is affected by changes in K+ as low as 0.1 mmol/L. The vasodilatory effect of K+ can be inhibited with simultaneous barium infusion, indicating that inward rectifier potassium (Kir)channels are involved. Acidosis has a direct effect on blood flow and an indirect effect, mediated by changes in other vasoactive compounds. Udgivelsesdato: 2007-Oct

AB - The analysis of blood samples has clearly demonstrated that exercise is associated with the release of K+ and H+ from muscle. However, blood samples give only incomplete information about the ion changes in the muscle interstitium. Interstitial changes in ion composition may affect the transport properties of the sarcolemmal membrane, may affect fibre excitability and induce fatigue, and may affect sensory nerve endings. Therefore, to better understand muscle function, it is important to quantify the exercise-induced interstitial ion changes. Both interstitial K+ and H+ changes have been quantified with the microdialysis technique. Interstitial K+ accumulation is dependent on the intensity and duration of muscle activity and may reach 10 mmol/L during intense exercise, and the concentration in T-tubules may be even higher. Thus, interstitial K+ can reach a level that affects fibre excitability and the development of fatigue. It has also been demonstrated with microdialysis that the interstitial decrease in pH during muscle activity is larger than the reduction in blood pH. Ion changes in the interstitium may affect blood flow directly or indirectly. Infusion of K+ into the femoral artery in humans has demonstrated that blood flow is affected by changes in K+ as low as 0.1 mmol/L. The vasodilatory effect of K+ can be inhibited with simultaneous barium infusion, indicating that inward rectifier potassium (Kir)channels are involved. Acidosis has a direct effect on blood flow and an indirect effect, mediated by changes in other vasoactive compounds. Udgivelsesdato: 2007-Oct

U2 - 10.1139/h07-065

DO - 10.1139/h07-065

M3 - Journal article

C2 - 18059608

SN - 1715-5312

VL - 32

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JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

IS - 5

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