TY - JOUR
T1 - Cerebral serotonin transporter measurements with [11C]DASB
T2 - A review on acquisition and preprocessing across 21 PET centres
AU - Nørgaard, Martin
AU - Ganz, Melanie
AU - Svarer, Claus
AU - Feng, Ling
AU - Ichise, Masanori
AU - Lanzenberger, Rupert
AU - Lubberink, Mark
AU - Parsey, Ramin V.
AU - Politis, Marios
AU - Rabiner, Eugenii A.
AU - Slifstein, Mark
AU - Sossi, Vesna
AU - Suhara, Tetsuya
AU - Talbot, Peter S.
AU - Turkheimer, Federico
AU - Strother, Stephen C.
AU - Knudsen, Gitte M.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to different outcomes and neurobiological interpretations. We here review the approaches used in 105 original research articles published by 21 different PET centres, using the tracer [11C]DASB for quantification of cerebral serotonin transporter binding, as an exemplary case. We highlight and quantify the impact of the remarkable variety of ways in which researchers are currently conducting their studies, while implicitly expecting generalizable results across research groups. Our review provides evidence that the foundation for a given choice of a preprocessing pipeline seems to be an overlooked aspect in modern PET neuroscience. Furthermore, we believe that a thorough testing of pipeline performance is necessary to produce reproducible research outcomes, avoiding biased results and allowing for better understanding of human brain function.
AB - Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to different outcomes and neurobiological interpretations. We here review the approaches used in 105 original research articles published by 21 different PET centres, using the tracer [11C]DASB for quantification of cerebral serotonin transporter binding, as an exemplary case. We highlight and quantify the impact of the remarkable variety of ways in which researchers are currently conducting their studies, while implicitly expecting generalizable results across research groups. Our review provides evidence that the foundation for a given choice of a preprocessing pipeline seems to be an overlooked aspect in modern PET neuroscience. Furthermore, we believe that a thorough testing of pipeline performance is necessary to produce reproducible research outcomes, avoiding biased results and allowing for better understanding of human brain function.
KW - data sharing
KW - kinetic modeling
KW - Positron Emission Tomography
KW - preprocessing
KW - [C]DASB
UR - http://www.scopus.com/inward/record.url?scp=85045328720&partnerID=8YFLogxK
U2 - 10.1177/0271678x18770107
DO - 10.1177/0271678x18770107
M3 - Review
C2 - 29651896
AN - SCOPUS:85045328720
SN - 0271-678X
VL - 39
SP - 210
EP - 222
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 2
ER -