Cerebral oximetry in preterm infants: An agenda for research with a clear clinical goal

TY - JOUR

T1 - Cerebral oximetry in preterm infants

T2 - An agenda for research with a clear clinical goal

AU - Greisen, Gorm

AU - Andresen, Bjørn

AU - Plomgaard, Anne Mette

AU - Hyttel-Sørensen, Simon

PY - 2016/7

Y1 - 2016/7

N2 - Preterm birth constitutes a major cause of death before 5 years of age and it is a major cause of neurodevelopmental impairment across the world. Preterm infants are most unstable during the transition between fetal and newborn life during the first days of life and most brain damage occurs in this period. The brain of the preterm infant is accessible for tissue oximetry by near-infrared spectroscopy. Cerebral oximetry has the potential to improve the long-term outcome by helping to tailor the support of respiration and circulation to the individual infant's needs, but the evidence is still lacking. The goals for research include testing the benefit and harms of cerebral oximetry in large-scale randomized trials, improved definition of the hypoxic threshold, better understanding the effects of intensive care on cerebral oxygenation, as well as improved precision of oximeters and calibration among devices or standardization of values in the hypoxic range. These goals can be pursued in parallel.

AB - Preterm birth constitutes a major cause of death before 5 years of age and it is a major cause of neurodevelopmental impairment across the world. Preterm infants are most unstable during the transition between fetal and newborn life during the first days of life and most brain damage occurs in this period. The brain of the preterm infant is accessible for tissue oximetry by near-infrared spectroscopy. Cerebral oximetry has the potential to improve the long-term outcome by helping to tailor the support of respiration and circulation to the individual infant's needs, but the evidence is still lacking. The goals for research include testing the benefit and harms of cerebral oximetry in large-scale randomized trials, improved definition of the hypoxic threshold, better understanding the effects of intensive care on cerebral oxygenation, as well as improved precision of oximeters and calibration among devices or standardization of values in the hypoxic range. These goals can be pursued in parallel.

KW - brain hypoxia

KW - brain injuries

KW - clinical study

KW - near-infrared spectroscopy

KW - preterm infant

U2 - 10.1117/1.NPh.3.3.031407

DO - 10.1117/1.NPh.3.3.031407

M3 - Journal article

C2 - 27158632

AN - SCOPUS:84978992757

SN - 2329-423X

VL - 3

JO - Neurophotonics

JF - Neurophotonics

IS - 3

M1 - 031407

ER -