Cerebral autoregulation in the preterm newborn using near-infrared spectroscopy: a comparison of time-domain and frequency-domain analyses

TY - JOUR

T1 - Cerebral autoregulation in the preterm newborn using near-infrared spectroscopy

T2 - a comparison of time-domain and frequency-domain analyses

AU - Eriksen, Vibeke R

AU - Hahn, Gitte H

AU - Greisen, Gorm

PY - 2015/3/1

Y1 - 2015/3/1

N2 - The aim was to compare two conventional methods used to describe cerebral autoregulation (CA): frequency-domain analysis and time-domain analysis. We measured cerebral oxygenation (as a surrogate for cerebral blood flow) and mean arterial blood pressure (MAP) in 60 preterm infants. In the frequency domain, outcome variables were coherence and gain, whereas the cerebral oximetry index (COx) and the regression coefficient were the outcome variables in the time domain. Correlation between coherence and COx was poor. The disagreement between the two methods was due to the MAP and cerebral oxygenation signals being in counterphase in three cases. High gain and high coherence may arise spuriously when cerebral oxygenation decreases as MAP increases; hence, time-domain analysis appears to be a more robust—and simpler—method to describe CA.

AB - The aim was to compare two conventional methods used to describe cerebral autoregulation (CA): frequency-domain analysis and time-domain analysis. We measured cerebral oxygenation (as a surrogate for cerebral blood flow) and mean arterial blood pressure (MAP) in 60 preterm infants. In the frequency domain, outcome variables were coherence and gain, whereas the cerebral oximetry index (COx) and the regression coefficient were the outcome variables in the time domain. Correlation between coherence and COx was poor. The disagreement between the two methods was due to the MAP and cerebral oxygenation signals being in counterphase in three cases. High gain and high coherence may arise spuriously when cerebral oxygenation decreases as MAP increases; hence, time-domain analysis appears to be a more robust—and simpler—method to describe CA.

U2 - 10.1117/1.JBO.20.3.037009

DO - 10.1117/1.JBO.20.3.037009

M3 - Journal article

C2 - 25806662

SN - 1083-3668

VL - 20

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

IS - 3

M1 - 037009

ER -