Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels

Anders Bue Klein; Viktorija Trajkovska; David Erritzoe; Steven Haugbol; Jacob Madsen; William Baaré; Susana Aznar; Gitte M Knudsen

doi:10.1038/jcbfm.2010.114

Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels

Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudsen

10 Citationer (Scopus)

Abstract

Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.

Originalsprog	Engelsk
Tidsskrift	Journal of Cerebral Blood Flow and Metabolism
Vol/bind	30
Udgave nummer	11
Sider (fra-til)	e1-7
ISSN	0271-678X
DOI	https://doi.org/10.1038/jcbfm.2010.114
Status	Udgivet - 1 nov. 2010

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10.1038/jcbfm.2010.114

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Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. / Klein, Anders Bue; Trajkovska, Viktorija; Erritzoe, David et al.
I: Journal of Cerebral Blood Flow and Metabolism, Bind 30, Nr. 11, 01.11.2010, s. e1-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels",

abstract = "Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.",

author = "Klein, {Anders Bue} and Viktorija Trajkovska and David Erritzoe and Steven Haugbol and Jacob Madsen and William Baar{\'e} and Susana Aznar and Knudsen, {Gitte M}",

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T1 - Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels

AU - Klein, Anders Bue

AU - Trajkovska, Viktorija

AU - Erritzoe, David

AU - Haugbol, Steven

AU - Madsen, Jacob

AU - Baaré, William

AU - Aznar, Susana

AU - Knudsen, Gitte M

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.

AB - Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.

U2 - 10.1038/jcbfm.2010.114

DO - 10.1038/jcbfm.2010.114

M3 - Journal article

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VL - 30

SP - e1-7

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 11

ER -

Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels

Abstract

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