Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis

Camilla S. L. Tuttle; Mariette E. C. Waaijer; Monique S. Slee-Valentijn; Theo Stijnen; Rudi Westendorp; Andrea B. Maier

doi:10.1111/acel.13083

Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis

Camilla S. L. Tuttle, Mariette E. C. Waaijer, Monique S. Slee-Valentijn, Theo Stijnen, Rudi Westendorp, Andrea B. Maier

14 Citationer (Scopus)

Abstract

Senescent cells in tissues and organs are considered to be pivotal to not only the aging process but also the onset of chronic disease. Accumulating evidence from animal experiments indicates that the magnitude of senescence can vary within and between aged tissue samples from the same animal. However, whether this variation in senescence translates across to human tissue samples is unknown. To address this fundamental question, we have conducted a systematic review and meta-analysis of all available literature investigating the magnitude of senescence and its association with chronological age in human tissue samples. While senescence is higher in aged tissue samples, the magnitude of senescence varies considerably depending upon tissue type, tissue section, and marker used to detect senescence. These findings echo animal experiments demonstrating that senescence levels may vary between organs within the same animal.

Originalsprog	Engelsk
Artikelnummer	e13083
Tidsskrift	Aging Cell
ISSN	1474-9718
DOI	https://doi.org/10.1111/acel.13083
Status	Udgivet - 1 feb. 2020

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10.1111/acel.13083Licens: CC BY

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title = "Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis",

abstract = "Senescent cells in tissues and organs are considered to be pivotal to not only the aging process but also the onset of chronic disease. Accumulating evidence from animal experiments indicates that the magnitude of senescence can vary within and between aged tissue samples from the same animal. However, whether this variation in senescence translates across to human tissue samples is unknown. To address this fundamental question, we have conducted a systematic review and meta-analysis of all available literature investigating the magnitude of senescence and its association with chronological age in human tissue samples. While senescence is higher in aged tissue samples, the magnitude of senescence varies considerably depending upon tissue type, tissue section, and marker used to detect senescence. These findings echo animal experiments demonstrating that senescence levels may vary between organs within the same animal.",

keywords = "aging, cell cycle proteins, cellular senescence, human, immunosenescence",

author = "Tuttle, {Camilla S. L.} and Waaijer, {Mariette E. C.} and Slee-Valentijn, {Monique S.} and Theo Stijnen and Rudi Westendorp and Maier, {Andrea B.}",

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doi = "10.1111/acel.13083",

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TY - JOUR

T1 - Cellular senescence and chronological age in various human tissues

T2 - A systematic review and meta-analysis

AU - Tuttle, Camilla S. L.

AU - Waaijer, Mariette E. C.

AU - Slee-Valentijn, Monique S.

AU - Stijnen, Theo

AU - Westendorp, Rudi

AU - Maier, Andrea B.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Senescent cells in tissues and organs are considered to be pivotal to not only the aging process but also the onset of chronic disease. Accumulating evidence from animal experiments indicates that the magnitude of senescence can vary within and between aged tissue samples from the same animal. However, whether this variation in senescence translates across to human tissue samples is unknown. To address this fundamental question, we have conducted a systematic review and meta-analysis of all available literature investigating the magnitude of senescence and its association with chronological age in human tissue samples. While senescence is higher in aged tissue samples, the magnitude of senescence varies considerably depending upon tissue type, tissue section, and marker used to detect senescence. These findings echo animal experiments demonstrating that senescence levels may vary between organs within the same animal.

AB - Senescent cells in tissues and organs are considered to be pivotal to not only the aging process but also the onset of chronic disease. Accumulating evidence from animal experiments indicates that the magnitude of senescence can vary within and between aged tissue samples from the same animal. However, whether this variation in senescence translates across to human tissue samples is unknown. To address this fundamental question, we have conducted a systematic review and meta-analysis of all available literature investigating the magnitude of senescence and its association with chronological age in human tissue samples. While senescence is higher in aged tissue samples, the magnitude of senescence varies considerably depending upon tissue type, tissue section, and marker used to detect senescence. These findings echo animal experiments demonstrating that senescence levels may vary between organs within the same animal.

KW - aging

KW - cell cycle proteins

KW - cellular senescence

KW - human

KW - immunosenescence

U2 - 10.1111/acel.13083

DO - 10.1111/acel.13083

M3 - Review

C2 - 31808308

SN - 1474-9718

JO - Aging Cell

JF - Aging Cell

M1 - e13083

ER -

Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis

Abstract

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