Cellular compartments cause multistability and allow cells to process more information

Heather A Harrington; Elisenda Feliu; Carsten Wiuf; Michael P H Stumpf

doi:10.1016/j.bpj.2013.02.028

Cellular compartments cause multistability and allow cells to process more information

Heather A Harrington, Elisenda Feliu, Carsten Wiuf, Michael P H Stumpf

Institut for Matematiske Fag

28 Citationer (Scopus)

Abstract

Many biological, physical, and social interactions have a particular dependence on where they take place; e.g., in living cells, protein movement between the nucleus and cytoplasm affects cellular responses (i.e., proteins must be present in the nucleus to regulate their target genes). Here we use recent developments from dynamical systems and chemical reaction network theory to identify and characterize the key-role of the spatial organization of eukaryotic cells in cellular information processing. In particular, the existence of distinct compartments plays a pivotal role in whether a system is capable of multistationarity (multiple response states), and is thus directly linked to the amount of information that the signaling molecules can represent in the nucleus. Multistationarity provides a mechanism for switching between different response states in cell signaling systems and enables multiple outcomes for cellular-decision making. We combine different mathematical techniques to provide a heuristic procedure to determine if a system has the capacity for multiple steady states, and find conditions that ensure that multiple steady states cannot occur. Notably, we find that introducing species localization can alter the capacity for multistationarity, and we mathematically demonstrate that shuttling confers flexibility for and greater control of the emergence of an all-or-nothing response of a cell.

Originalsprog	Engelsk
Tidsskrift	Biophysical Journal
Vol/bind	104
Udgave nummer	8
Sider (fra-til)	1824-1831
Antal sider	8
ISSN	0006-3495
DOI	https://doi.org/10.1016/j.bpj.2013.02.028
Status	Udgivet - 16 apr. 2013

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10.1016/j.bpj.2013.02.028

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abstract = "Many biological, physical, and social interactions have a particular dependence on where they take place; e.g., in living cells, protein movement between the nucleus and cytoplasm affects cellular responses (i.e., proteins must be present in the nucleus to regulate their target genes). Here we use recent developments from dynamical systems and chemical reaction network theory to identify and characterize the key-role of the spatial organization of eukaryotic cells in cellular information processing. In particular, the existence of distinct compartments plays a pivotal role in whether a system is capable of multistationarity (multiple response states), and is thus directly linked to the amount of information that the signaling molecules can represent in the nucleus. Multistationarity provides a mechanism for switching between different response states in cell signaling systems and enables multiple outcomes for cellular-decision making. We combine different mathematical techniques to provide a heuristic procedure to determine if a system has the capacity for multiple steady states, and find conditions that ensure that multiple steady states cannot occur. Notably, we find that introducing species localization can alter the capacity for multistationarity, and we mathematically demonstrate that shuttling confers flexibility for and greater control of the emergence of an all-or-nothing response of a cell.",

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T1 - Cellular compartments cause multistability and allow cells to process more information

AU - Harrington, Heather A

AU - Feliu, Elisenda

AU - Wiuf, Carsten

AU - Stumpf, Michael P H

PY - 2013/4/16

Y1 - 2013/4/16

N2 - Many biological, physical, and social interactions have a particular dependence on where they take place; e.g., in living cells, protein movement between the nucleus and cytoplasm affects cellular responses (i.e., proteins must be present in the nucleus to regulate their target genes). Here we use recent developments from dynamical systems and chemical reaction network theory to identify and characterize the key-role of the spatial organization of eukaryotic cells in cellular information processing. In particular, the existence of distinct compartments plays a pivotal role in whether a system is capable of multistationarity (multiple response states), and is thus directly linked to the amount of information that the signaling molecules can represent in the nucleus. Multistationarity provides a mechanism for switching between different response states in cell signaling systems and enables multiple outcomes for cellular-decision making. We combine different mathematical techniques to provide a heuristic procedure to determine if a system has the capacity for multiple steady states, and find conditions that ensure that multiple steady states cannot occur. Notably, we find that introducing species localization can alter the capacity for multistationarity, and we mathematically demonstrate that shuttling confers flexibility for and greater control of the emergence of an all-or-nothing response of a cell.

AB - Many biological, physical, and social interactions have a particular dependence on where they take place; e.g., in living cells, protein movement between the nucleus and cytoplasm affects cellular responses (i.e., proteins must be present in the nucleus to regulate their target genes). Here we use recent developments from dynamical systems and chemical reaction network theory to identify and characterize the key-role of the spatial organization of eukaryotic cells in cellular information processing. In particular, the existence of distinct compartments plays a pivotal role in whether a system is capable of multistationarity (multiple response states), and is thus directly linked to the amount of information that the signaling molecules can represent in the nucleus. Multistationarity provides a mechanism for switching between different response states in cell signaling systems and enables multiple outcomes for cellular-decision making. We combine different mathematical techniques to provide a heuristic procedure to determine if a system has the capacity for multiple steady states, and find conditions that ensure that multiple steady states cannot occur. Notably, we find that introducing species localization can alter the capacity for multistationarity, and we mathematically demonstrate that shuttling confers flexibility for and greater control of the emergence of an all-or-nothing response of a cell.

U2 - 10.1016/j.bpj.2013.02.028

DO - 10.1016/j.bpj.2013.02.028

M3 - Journal article

C2 - 23601329

SN - 0006-3495

VL - 104

SP - 1824

EP - 1831

JO - Biophysical Journal

JF - Biophysical Journal

IS - 8

ER -

Cellular compartments cause multistability and allow cells to process more information

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