Abstract
Adherens junctions have been traditionally viewed as building blocks of tissue architecture. The foundations for this view began to change with the discovery that a central component of AJs, beta-catenin, can also function as a transcriptional cofactor in Wnt signaling. In recent years, conventional views have similarly been shaken about the other two major AJ catenins, alpha-catenin and p120-catenin. Catenins have emerged as molecular sensors that integrate cell-cell junctions and cytoskeletal dynamics with signaling pathways that govern morphogenesis, tissue homeostasis, and even intercellular communication between different cell types within a tissue. These findings reveal novel aspects of AJ function in normal tissues and offer insights into how changes in AJs and their associated proteins and cytoskeletal dynamics impact wound-repair and cancer.
Originalsprog | Engelsk |
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Tidsskrift | Developmental Cell |
Vol/bind | 11 |
Udgave nummer | 5 |
Sider (fra-til) | 601-12 |
Antal sider | 12 |
ISSN | 1534-5807 |
DOI | |
Status | Udgivet - nov. 2006 |