Catenins: keeping cells from getting their signals crossed

Mirna Perez-Moreno, Elaine Fuchs

209 Citationer (Scopus)

Abstract

Adherens junctions have been traditionally viewed as building blocks of tissue architecture. The foundations for this view began to change with the discovery that a central component of AJs, beta-catenin, can also function as a transcriptional cofactor in Wnt signaling. In recent years, conventional views have similarly been shaken about the other two major AJ catenins, alpha-catenin and p120-catenin. Catenins have emerged as molecular sensors that integrate cell-cell junctions and cytoskeletal dynamics with signaling pathways that govern morphogenesis, tissue homeostasis, and even intercellular communication between different cell types within a tissue. These findings reveal novel aspects of AJ function in normal tissues and offer insights into how changes in AJs and their associated proteins and cytoskeletal dynamics impact wound-repair and cancer.

OriginalsprogEngelsk
TidsskriftDevelopmental Cell
Vol/bind11
Udgave nummer5
Sider (fra-til)601-12
Antal sider12
ISSN1534-5807
DOI
StatusUdgivet - nov. 2006

Fingeraftryk

Dyk ned i forskningsemnerne om 'Catenins: keeping cells from getting their signals crossed'. Sammen danner de et unikt fingeraftryk.

Citationsformater