Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection

Mahtab Chehri; Alice Højer Christensen; Sofie Ingdam Halkjær; Stig Günther; Andreas Munk Petersen; Morten Helms

doi:10.1097/md.0000000000011706

Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection

Mahtab Chehri, Alice Højer Christensen, Sofie Ingdam Halkjær, Stig Günther, Andreas Munk Petersen, Morten Helms

Institut for Klinisk Medicin

3 Citationer (Scopus)

Abstract

Rationale: Studies have shown that fecal microbiota transplantation (FMT) is a safe and highly efficient treatment for recurrent Clostridium difficile infection (rCDI). However, it is still unknown if one versus multiple donors or enemas versus capsule FMT are most efficient. Patient concerns: 10 patients with at least 3 previous episodes of CDI were offered treatment with FMT capsules. 9 patients decided to participate. Diagnoses: In this study, we treated 9 patients (25–86 years) with rCDI. Interventions: From October to November 2016, a total of 9 patients with recurrent CDI were treated with oral fecal microbiota capsules, with mixed donor feces from 4 donors with high microbiota diversity. All patients received treatment with vancomycin prior to the capsule regime. Outcome: Patients had previous recurrences ranging from 2 to 10 recurrences. All 9 patients were successfully treated without recurrence after 180 days follow-up, even 2 patients previously treated with FMT enemas. Lessons: FMT capsules based on multiple donors are highly efficient in patients with rCDI. Abbreviations: CDI = Clostridium difficile infection, FMT = fecal microbiota transplantation, RBT = rectal bacteriotherapy, rCDI = recurrent CDI.

Originalsprog	Engelsk
Tidsskrift	Medicine
Vol/bind	97
Udgave nummer	31
Sider (fra-til)	e11706
ISSN	0025-7974
DOI	https://doi.org/10.1097/md.0000000000011706
Status	Udgivet - 2018

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10.1097/md.0000000000011706Licens: CC BY-NC

http://europepmc.org/articles/pmc6081131?pdf=renderLicens: CC BY-NC-ND

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Citationsformater

Chehri, M., Christensen, A. H., Halkjær, S. I., Günther, S., Petersen, A. M., & Helms, M. (2018). Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection. Medicine, 97(31), e11706. https://doi.org/10.1097/md.0000000000011706

Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection. / Chehri, Mahtab; Christensen, Alice Højer; Halkjær, Sofie Ingdam et al.
I: Medicine, Bind 97, Nr. 31, 2018, s. e11706.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Chehri, M, Christensen, AH, Halkjær, SI, Günther, S, Petersen, AM & Helms, M 2018, 'Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection', Medicine, bind 97, nr. 31, s. e11706. https://doi.org/10.1097/md.0000000000011706

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title = "Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection",

abstract = "Rationale: Studies have shown that fecal microbiota transplantation (FMT) is a safe and highly efficient treatment for recurrent Clostridium difficile infection (rCDI). However, it is still unknown if one versus multiple donors or enemas versus capsule FMT are most efficient. Patient concerns: 10 patients with at least 3 previous episodes of CDI were offered treatment with FMT capsules. 9 patients decided to participate. Diagnoses: In this study, we treated 9 patients (25–86 years) with rCDI. Interventions: From October to November 2016, a total of 9 patients with recurrent CDI were treated with oral fecal microbiota capsules, with mixed donor feces from 4 donors with high microbiota diversity. All patients received treatment with vancomycin prior to the capsule regime. Outcome: Patients had previous recurrences ranging from 2 to 10 recurrences. All 9 patients were successfully treated without recurrence after 180 days follow-up, even 2 patients previously treated with FMT enemas. Lessons: FMT capsules based on multiple donors are highly efficient in patients with rCDI. Abbreviations: CDI = Clostridium difficile infection, FMT = fecal microbiota transplantation, RBT = rectal bacteriotherapy, rCDI = recurrent CDI.",

author = "Mahtab Chehri and Christensen, {Alice H{\o}jer} and Halkj{\ae}r, {Sofie Ingdam} and Stig G{\"u}nther and Petersen, {Andreas Munk} and Morten Helms",

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AU - Chehri, Mahtab

AU - Christensen, Alice Højer

AU - Halkjær, Sofie Ingdam

AU - Günther, Stig

AU - Petersen, Andreas Munk

AU - Helms, Morten

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N2 - Rationale: Studies have shown that fecal microbiota transplantation (FMT) is a safe and highly efficient treatment for recurrent Clostridium difficile infection (rCDI). However, it is still unknown if one versus multiple donors or enemas versus capsule FMT are most efficient. Patient concerns: 10 patients with at least 3 previous episodes of CDI were offered treatment with FMT capsules. 9 patients decided to participate. Diagnoses: In this study, we treated 9 patients (25–86 years) with rCDI. Interventions: From October to November 2016, a total of 9 patients with recurrent CDI were treated with oral fecal microbiota capsules, with mixed donor feces from 4 donors with high microbiota diversity. All patients received treatment with vancomycin prior to the capsule regime. Outcome: Patients had previous recurrences ranging from 2 to 10 recurrences. All 9 patients were successfully treated without recurrence after 180 days follow-up, even 2 patients previously treated with FMT enemas. Lessons: FMT capsules based on multiple donors are highly efficient in patients with rCDI. Abbreviations: CDI = Clostridium difficile infection, FMT = fecal microbiota transplantation, RBT = rectal bacteriotherapy, rCDI = recurrent CDI.

AB - Rationale: Studies have shown that fecal microbiota transplantation (FMT) is a safe and highly efficient treatment for recurrent Clostridium difficile infection (rCDI). However, it is still unknown if one versus multiple donors or enemas versus capsule FMT are most efficient. Patient concerns: 10 patients with at least 3 previous episodes of CDI were offered treatment with FMT capsules. 9 patients decided to participate. Diagnoses: In this study, we treated 9 patients (25–86 years) with rCDI. Interventions: From October to November 2016, a total of 9 patients with recurrent CDI were treated with oral fecal microbiota capsules, with mixed donor feces from 4 donors with high microbiota diversity. All patients received treatment with vancomycin prior to the capsule regime. Outcome: Patients had previous recurrences ranging from 2 to 10 recurrences. All 9 patients were successfully treated without recurrence after 180 days follow-up, even 2 patients previously treated with FMT enemas. Lessons: FMT capsules based on multiple donors are highly efficient in patients with rCDI. Abbreviations: CDI = Clostridium difficile infection, FMT = fecal microbiota transplantation, RBT = rectal bacteriotherapy, rCDI = recurrent CDI.

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