Cartilage cavity: an MRI marker of cartilage lesions in knee OA with Data from CCBR, OAI, and PROOF

Erik B Dam; Jos Runhaar; Sita Bierma-Zienstra; Morten Karsdal

doi:10.1002/mrm.27130

Cartilage cavity: an MRI marker of cartilage lesions in knee OA with Data from CCBR, OAI, and PROOF

Erik B Dam, Jos Runhaar, Sita Bierma-Zienstra, Morten Karsdal

4 Citationer (Scopus)

Abstract

PURPOSE: We introduce the quantitative, continuous marker cartilage cavity that quantifies cartilage lesions by the total lesion volume. The aim was to quantify small lesions as well as large, full-depth lesions.

METHODS: We included 315 knees from the Center for Clinical and Basic Research (CCBR), 972 knees from the Osteoarthritis Initiative (OAI), and 791 knees from the Prevention of OA in Overweight Females (PROOF) cohorts. In a subset, we digitally inserted artificial lesions. Each knee MRI was segmented using the knee imaging quantification (KIQ) framework. We quantified cartilage mean thickness and cavity from high-resolution cartilage thickness maps. Finally, we quantified lesion volume by the gradient peak method (GPM).

RESULTS: Scan-rescan precision for cartilage cavity was 7.1%/3.0%. The cartilage cavity accuracy on the artificial lesions was determined as linear correlation at 0.88 with an average 8% under-estimation of lesion volume. Cavity and degree of radiographic osteoarthritis (ROA) correlated for all compartments (Spearman's rho between 0.14-0.56, P < 0.001). Cavity had modest correlations to whole-organ magnetic resonance imaging score (WORMS) cartilage lesion scores but strong correlations with Boston-Leeds osteoarthritis knee score (BLOKS)/MRI osteoarthritis knee score (MOAKS) scores in most compartments (rho between 0.08-0.65, P < 0.001). Cavity correlated with WOMAC pain for all tibio-femoral compartments in OAI (rho between 0.19-0.25, P < 0.001) and most compartments in PROOF. Comparing with the GPM estimate, cavity was more precise, more accurate, and correlated stronger with ROA, lesion scores, and pain levels.

CONCLUSION: The strong correlations with ROA, radiologist lesion scores, and pain demonstrated that cavity captured OA and lesion features. Thereby, it may be appropriate for quantification of cartilage surface irregularity.

Originalsprog	Engelsk
Tidsskrift	Magnetic Resonance in Medicine
Vol/bind	80
Udgave nummer	3
Sider (fra-til)	1219-1232
ISSN	0740-3194
DOI	https://doi.org/10.1002/mrm.27130
Status	Udgivet - 2018

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10.1002/mrm.27130

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title = "Cartilage cavity: an MRI marker of cartilage lesions in knee OA with Data from CCBR, OAI, and PROOF",

abstract = "PURPOSE: We introduce the quantitative, continuous marker cartilage cavity that quantifies cartilage lesions by the total lesion volume. The aim was to quantify small lesions as well as large, full-depth lesions.METHODS: We included 315 knees from the Center for Clinical and Basic Research (CCBR), 972 knees from the Osteoarthritis Initiative (OAI), and 791 knees from the Prevention of OA in Overweight Females (PROOF) cohorts. In a subset, we digitally inserted artificial lesions. Each knee MRI was segmented using the knee imaging quantification (KIQ) framework. We quantified cartilage mean thickness and cavity from high-resolution cartilage thickness maps. Finally, we quantified lesion volume by the gradient peak method (GPM).RESULTS: Scan-rescan precision for cartilage cavity was 7.1%/3.0%. The cartilage cavity accuracy on the artificial lesions was determined as linear correlation at 0.88 with an average 8% under-estimation of lesion volume. Cavity and degree of radiographic osteoarthritis (ROA) correlated for all compartments (Spearman's rho between 0.14-0.56, P < 0.001). Cavity had modest correlations to whole-organ magnetic resonance imaging score (WORMS) cartilage lesion scores but strong correlations with Boston-Leeds osteoarthritis knee score (BLOKS)/MRI osteoarthritis knee score (MOAKS) scores in most compartments (rho between 0.08-0.65, P < 0.001). Cavity correlated with WOMAC pain for all tibio-femoral compartments in OAI (rho between 0.19-0.25, P < 0.001) and most compartments in PROOF. Comparing with the GPM estimate, cavity was more precise, more accurate, and correlated stronger with ROA, lesion scores, and pain levels.CONCLUSION: The strong correlations with ROA, radiologist lesion scores, and pain demonstrated that cavity captured OA and lesion features. Thereby, it may be appropriate for quantification of cartilage surface irregularity.",

keywords = "biomarker, cartilage, integrity, osteoarthritis",

author = "Dam, {Erik B} and Jos Runhaar and Sita Bierma-Zienstra and Morten Karsdal",

note = "{\textcopyright} 2018 International Society for Magnetic Resonance in Medicine.",

year = "2018",

doi = "10.1002/mrm.27130",

language = "English",

volume = "80",

pages = "1219--1232",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "JohnWiley & Sons, Inc.",

number = "3",

}

TY - JOUR

T1 - Cartilage cavity

T2 - an MRI marker of cartilage lesions in knee OA with Data from CCBR, OAI, and PROOF

AU - Dam, Erik B

AU - Runhaar, Jos

AU - Bierma-Zienstra, Sita

AU - Karsdal, Morten

PY - 2018

Y1 - 2018

N2 - PURPOSE: We introduce the quantitative, continuous marker cartilage cavity that quantifies cartilage lesions by the total lesion volume. The aim was to quantify small lesions as well as large, full-depth lesions.METHODS: We included 315 knees from the Center for Clinical and Basic Research (CCBR), 972 knees from the Osteoarthritis Initiative (OAI), and 791 knees from the Prevention of OA in Overweight Females (PROOF) cohorts. In a subset, we digitally inserted artificial lesions. Each knee MRI was segmented using the knee imaging quantification (KIQ) framework. We quantified cartilage mean thickness and cavity from high-resolution cartilage thickness maps. Finally, we quantified lesion volume by the gradient peak method (GPM).RESULTS: Scan-rescan precision for cartilage cavity was 7.1%/3.0%. The cartilage cavity accuracy on the artificial lesions was determined as linear correlation at 0.88 with an average 8% under-estimation of lesion volume. Cavity and degree of radiographic osteoarthritis (ROA) correlated for all compartments (Spearman's rho between 0.14-0.56, P < 0.001). Cavity had modest correlations to whole-organ magnetic resonance imaging score (WORMS) cartilage lesion scores but strong correlations with Boston-Leeds osteoarthritis knee score (BLOKS)/MRI osteoarthritis knee score (MOAKS) scores in most compartments (rho between 0.08-0.65, P < 0.001). Cavity correlated with WOMAC pain for all tibio-femoral compartments in OAI (rho between 0.19-0.25, P < 0.001) and most compartments in PROOF. Comparing with the GPM estimate, cavity was more precise, more accurate, and correlated stronger with ROA, lesion scores, and pain levels.CONCLUSION: The strong correlations with ROA, radiologist lesion scores, and pain demonstrated that cavity captured OA and lesion features. Thereby, it may be appropriate for quantification of cartilage surface irregularity.

AB - PURPOSE: We introduce the quantitative, continuous marker cartilage cavity that quantifies cartilage lesions by the total lesion volume. The aim was to quantify small lesions as well as large, full-depth lesions.METHODS: We included 315 knees from the Center for Clinical and Basic Research (CCBR), 972 knees from the Osteoarthritis Initiative (OAI), and 791 knees from the Prevention of OA in Overweight Females (PROOF) cohorts. In a subset, we digitally inserted artificial lesions. Each knee MRI was segmented using the knee imaging quantification (KIQ) framework. We quantified cartilage mean thickness and cavity from high-resolution cartilage thickness maps. Finally, we quantified lesion volume by the gradient peak method (GPM).RESULTS: Scan-rescan precision for cartilage cavity was 7.1%/3.0%. The cartilage cavity accuracy on the artificial lesions was determined as linear correlation at 0.88 with an average 8% under-estimation of lesion volume. Cavity and degree of radiographic osteoarthritis (ROA) correlated for all compartments (Spearman's rho between 0.14-0.56, P < 0.001). Cavity had modest correlations to whole-organ magnetic resonance imaging score (WORMS) cartilage lesion scores but strong correlations with Boston-Leeds osteoarthritis knee score (BLOKS)/MRI osteoarthritis knee score (MOAKS) scores in most compartments (rho between 0.08-0.65, P < 0.001). Cavity correlated with WOMAC pain for all tibio-femoral compartments in OAI (rho between 0.19-0.25, P < 0.001) and most compartments in PROOF. Comparing with the GPM estimate, cavity was more precise, more accurate, and correlated stronger with ROA, lesion scores, and pain levels.CONCLUSION: The strong correlations with ROA, radiologist lesion scores, and pain demonstrated that cavity captured OA and lesion features. Thereby, it may be appropriate for quantification of cartilage surface irregularity.

KW - biomarker

KW - cartilage

KW - integrity

KW - osteoarthritis

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U2 - 10.1002/mrm.27130

DO - 10.1002/mrm.27130

M3 - Journal article

C2 - 29493000

SN - 0740-3194

VL - 80

SP - 1219

EP - 1232

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 3

ER -

Cartilage cavity: an MRI marker of cartilage lesions in knee OA with Data from CCBR, OAI, and PROOF

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