Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

Imran Rashid; David M van Reyk; Michael Jonathan Davies

doi:10.1016/j.febslet.2007.01.082

Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

Imran Rashid, David M van Reyk, Michael Jonathan Davies

84 Citationer (Scopus)

Abstract

Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids beta-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis.

Originalsprog	Engelsk
Tidsskrift	FEBS Letters
Vol/bind	581
Udgave nummer	5
Sider (fra-til)	1067-70
Antal sider	4
ISSN	0014-5793
DOI	https://doi.org/10.1016/j.febslet.2007.01.082
Status	Udgivet - 6 mar. 2007
Udgivet eksternt	Ja

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10.1016/j.febslet.2007.01.082

Citationsformater

@article{b6cedd49d7594ac496de8a3e4ff0d8c7,

title = "Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro",

abstract = "Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids beta-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis.",

keywords = "Cardiovascular Diseases, Carnosine, Diabetic Angiopathies, Foam Cells, Glycosylation, Histidine, Humans, In Vitro Techniques, Lipoproteins, LDL, Macrophages, beta-Alanine",

author = "Imran Rashid and {van Reyk}, {David M} and Davies, {Michael Jonathan}",

year = "2007",

month = mar,

day = "6",

doi = "10.1016/j.febslet.2007.01.082",

language = "English",

volume = "581",

pages = "1067--70",

journal = "F E B S Letters",

issn = "0014-5793",

publisher = "JohnWiley & Sons Ltd",

number = "5",

}

TY - JOUR

T1 - Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

AU - Rashid, Imran

AU - van Reyk, David M

AU - Davies, Michael Jonathan

PY - 2007/3/6

Y1 - 2007/3/6

N2 - Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids beta-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis.

AB - Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids beta-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis.

KW - Cardiovascular Diseases

KW - Carnosine

KW - Diabetic Angiopathies

KW - Foam Cells

KW - Glycosylation

KW - Histidine

KW - Humans

KW - In Vitro Techniques

KW - Lipoproteins, LDL

KW - Macrophages

KW - beta-Alanine

U2 - 10.1016/j.febslet.2007.01.082

DO - 10.1016/j.febslet.2007.01.082

M3 - Journal article

C2 - 17316626

SN - 0014-5793

VL - 581

SP - 1067

EP - 1070

JO - F E B S Letters

JF - F E B S Letters

IS - 5

ER -

Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

Abstract

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