Cardiovascular risk in patients with sleep apnoea with or without continuous positive airway pressure therapy: follow-up of 4.5 million Danish adults

Morten Lamberts; O W Nielsen; G Y H Lip; Martin Huth Ruwald; Christine Benn Christiansen; Søren Lund Kristensen; Christian Torp-Pedersen; Morten Lock Hansen; G H Gislason

doi:10.1111/joim.12302

Cardiovascular risk in patients with sleep apnoea with or without continuous positive airway pressure therapy: follow-up of 4.5 million Danish adults

Morten Lamberts, O W Nielsen, G Y H Lip, Martin Huth Ruwald, Christine Benn Christiansen, Søren Lund Kristensen, Christian Torp-Pedersen, Morten Lock Hansen, G H Gislason

Institut for Klinisk Medicin

35 Citationer (Scopus)

Abstract

BACKGROUND: The prognostic significance of age and continuous positive airway pressure (CPAP) therapy on cardiovascular disease in patients with sleep apnoea has not been assessed previously.

METHODS: Using nationwide databases, the entire Danish population was followed from 2000 until 2011. First-time sleep apnoea diagnoses and use of CPAP therapy were determined. Incidence rate ratios (IRRs) of ischaemic stroke and myocardial infarction (MI) were analysed using Poisson regression models.

RESULTS: Amongst 4.5 million individuals included in the study, 33 274 developed sleep apnoea (mean age 53, 79% men) of whom 44% received persistent CPAP therapy. Median time to initiation of CPAP therapy was 88 days (interquartile range 34-346). Patients with sleep apnoea had more comorbidities compared to the general population. Crude rates of MI and ischaemic stroke were increased for sleep apnoea patients (5.4 and 3.6 events per 1000 person-years compared to 4.0 and 3.0 in the general population, respectively). Relative to the general population, risk of MI [IRR 1.71, 95% confidence interval (CI) 1.57-1.86] and ischaemic stroke (IRR 1.50, 95% CI 1.35-1.66) was significantly increased in patients with sleep apnoea, in particular in patients younger than 50 years (IRR 2.12, 95% CI 1.64-2.74 and IRR 2.34, 95% CI 1.77-3.10, respectively). Subsequent CPAP therapy was not associated with altered prognosis.

CONCLUSIONS: Sleep apnoea is associated with increased risk of ischaemic stroke and MI, particularly in patients younger than 50 years of age. CPAP therapy was not associated with a reduced rate of stroke or MI.

Originalsprog	Engelsk
Tidsskrift	Journal of Internal Medicine
Vol/bind	276
Udgave nummer	6
Sider (fra-til)	659-666
Antal sider	8
ISSN	0954-6820
DOI	https://doi.org/10.1111/joim.12302
Status	Udgivet - 1 dec. 2014

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10.1111/joim.12302

Citationsformater

Lamberts, M., Nielsen, O. W., Lip, G. Y. H., Ruwald, M. H., Christiansen, C. B., Kristensen, S. L., Torp-Pedersen, C., Hansen, M. L., & Gislason, G. H. (2014). Cardiovascular risk in patients with sleep apnoea with or without continuous positive airway pressure therapy: follow-up of 4.5 million Danish adults. Journal of Internal Medicine, 276(6), 659-666. https://doi.org/10.1111/joim.12302

Lamberts, M, Nielsen, OW, Lip, GYH, Ruwald, MH, Christiansen, CB, Kristensen, SL, Torp-Pedersen, C, Hansen, ML & Gislason, GH 2014, 'Cardiovascular risk in patients with sleep apnoea with or without continuous positive airway pressure therapy: follow-up of 4.5 million Danish adults', Journal of Internal Medicine, bind 276, nr. 6, s. 659-666. https://doi.org/10.1111/joim.12302

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title = "Cardiovascular risk in patients with sleep apnoea with or without continuous positive airway pressure therapy: follow-up of 4.5 million Danish adults",

abstract = "BACKGROUND: The prognostic significance of age and continuous positive airway pressure (CPAP) therapy on cardiovascular disease in patients with sleep apnoea has not been assessed previously.METHODS: Using nationwide databases, the entire Danish population was followed from 2000 until 2011. First-time sleep apnoea diagnoses and use of CPAP therapy were determined. Incidence rate ratios (IRRs) of ischaemic stroke and myocardial infarction (MI) were analysed using Poisson regression models.RESULTS: Amongst 4.5 million individuals included in the study, 33 274 developed sleep apnoea (mean age 53, 79% men) of whom 44% received persistent CPAP therapy. Median time to initiation of CPAP therapy was 88 days (interquartile range 34-346). Patients with sleep apnoea had more comorbidities compared to the general population. Crude rates of MI and ischaemic stroke were increased for sleep apnoea patients (5.4 and 3.6 events per 1000 person-years compared to 4.0 and 3.0 in the general population, respectively). Relative to the general population, risk of MI [IRR 1.71, 95% confidence interval (CI) 1.57-1.86] and ischaemic stroke (IRR 1.50, 95% CI 1.35-1.66) was significantly increased in patients with sleep apnoea, in particular in patients younger than 50 years (IRR 2.12, 95% CI 1.64-2.74 and IRR 2.34, 95% CI 1.77-3.10, respectively). Subsequent CPAP therapy was not associated with altered prognosis.CONCLUSIONS: Sleep apnoea is associated with increased risk of ischaemic stroke and MI, particularly in patients younger than 50 years of age. CPAP therapy was not associated with a reduced rate of stroke or MI.",

keywords = "Age Factors, Brain Ischemia, Comorbidity, Continuous Positive Airway Pressure, Denmark, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Myocardial Infarction, Poisson Distribution, Risk Factors, Sleep Apnea Syndromes, Stroke",

author = "Morten Lamberts and Nielsen, {O W} and Lip, {G Y H} and Ruwald, {Martin Huth} and Christiansen, {Christine Benn} and Kristensen, {S{\o}ren Lund} and Christian Torp-Pedersen and Hansen, {Morten Lock} and Gislason, {G H}",

note = "{\textcopyright} 2014 The Association for the Publication of the Journal of Internal Medicine.",

year = "2014",

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doi = "10.1111/joim.12302",

language = "English",

volume = "276",

pages = "659--666",

journal = "Journal of Internal Medicine",

issn = "0954-6820",

publisher = "Wiley-Blackwell",

number = "6",

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TY - JOUR

T1 - Cardiovascular risk in patients with sleep apnoea with or without continuous positive airway pressure therapy

T2 - follow-up of 4.5 million Danish adults

AU - Lamberts, Morten

AU - Nielsen, O W

AU - Lip, G Y H

AU - Ruwald, Martin Huth

AU - Christiansen, Christine Benn

AU - Kristensen, Søren Lund

AU - Torp-Pedersen, Christian

AU - Hansen, Morten Lock

AU - Gislason, G H

PY - 2014/12/1

Y1 - 2014/12/1

N2 - BACKGROUND: The prognostic significance of age and continuous positive airway pressure (CPAP) therapy on cardiovascular disease in patients with sleep apnoea has not been assessed previously.METHODS: Using nationwide databases, the entire Danish population was followed from 2000 until 2011. First-time sleep apnoea diagnoses and use of CPAP therapy were determined. Incidence rate ratios (IRRs) of ischaemic stroke and myocardial infarction (MI) were analysed using Poisson regression models.RESULTS: Amongst 4.5 million individuals included in the study, 33 274 developed sleep apnoea (mean age 53, 79% men) of whom 44% received persistent CPAP therapy. Median time to initiation of CPAP therapy was 88 days (interquartile range 34-346). Patients with sleep apnoea had more comorbidities compared to the general population. Crude rates of MI and ischaemic stroke were increased for sleep apnoea patients (5.4 and 3.6 events per 1000 person-years compared to 4.0 and 3.0 in the general population, respectively). Relative to the general population, risk of MI [IRR 1.71, 95% confidence interval (CI) 1.57-1.86] and ischaemic stroke (IRR 1.50, 95% CI 1.35-1.66) was significantly increased in patients with sleep apnoea, in particular in patients younger than 50 years (IRR 2.12, 95% CI 1.64-2.74 and IRR 2.34, 95% CI 1.77-3.10, respectively). Subsequent CPAP therapy was not associated with altered prognosis.CONCLUSIONS: Sleep apnoea is associated with increased risk of ischaemic stroke and MI, particularly in patients younger than 50 years of age. CPAP therapy was not associated with a reduced rate of stroke or MI.

AB - BACKGROUND: The prognostic significance of age and continuous positive airway pressure (CPAP) therapy on cardiovascular disease in patients with sleep apnoea has not been assessed previously.METHODS: Using nationwide databases, the entire Danish population was followed from 2000 until 2011. First-time sleep apnoea diagnoses and use of CPAP therapy were determined. Incidence rate ratios (IRRs) of ischaemic stroke and myocardial infarction (MI) were analysed using Poisson regression models.RESULTS: Amongst 4.5 million individuals included in the study, 33 274 developed sleep apnoea (mean age 53, 79% men) of whom 44% received persistent CPAP therapy. Median time to initiation of CPAP therapy was 88 days (interquartile range 34-346). Patients with sleep apnoea had more comorbidities compared to the general population. Crude rates of MI and ischaemic stroke were increased for sleep apnoea patients (5.4 and 3.6 events per 1000 person-years compared to 4.0 and 3.0 in the general population, respectively). Relative to the general population, risk of MI [IRR 1.71, 95% confidence interval (CI) 1.57-1.86] and ischaemic stroke (IRR 1.50, 95% CI 1.35-1.66) was significantly increased in patients with sleep apnoea, in particular in patients younger than 50 years (IRR 2.12, 95% CI 1.64-2.74 and IRR 2.34, 95% CI 1.77-3.10, respectively). Subsequent CPAP therapy was not associated with altered prognosis.CONCLUSIONS: Sleep apnoea is associated with increased risk of ischaemic stroke and MI, particularly in patients younger than 50 years of age. CPAP therapy was not associated with a reduced rate of stroke or MI.

KW - Age Factors

KW - Brain Ischemia

KW - Comorbidity

KW - Continuous Positive Airway Pressure

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Poisson Distribution

KW - Risk Factors

KW - Sleep Apnea Syndromes

KW - Stroke

U2 - 10.1111/joim.12302

DO - 10.1111/joim.12302

M3 - Journal article

C2 - 25169419

SN - 0954-6820

VL - 276

SP - 659

EP - 666

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

IS - 6

ER -

Cardiovascular risk in patients with sleep apnoea with or without continuous positive airway pressure therapy: follow-up of 4.5 million Danish adults

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