Cardiac perfusion and function after high-intensity exercise training in late premenopausal and recent postmenopausal women: An MRI study

TY - JOUR

T1 - Cardiac perfusion and function after high-intensity exercise training in late premenopausal and recent postmenopausal women

T2 - An MRI study

AU - Egelund, Jon

AU - Nyberg, Michael Permin

AU - Mandrup, Camilla M

AU - Abdulla, Jawdat

AU - Stallknecht, Bente

AU - Bangsbo, Jens

AU - Hellsten, Ylva

AU - Larsson, Henrik Bo Wiberg

N1 - CURIS 2019 NEXS 164

PY - 2019/5

Y1 - 2019/5

N2 - We examined the influence of recent menopause and aerobic exercise training in women on myocardial perfusion, left ventricular (LV) dimension, and function. Two groups (n 14 each) of healthy late premenopausal (50.2 2.1 yr) and recent postmenopausal (54.2 2.8 yr) women underwent cardiac magnetic resonance imaging (cMRI) at baseline and after 12 wk of high-intensity aerobic training. Measurements included LV morphology, systolic function, and myocardial perfusion at rest and during an adenosine stress test. At baseline, resting myocardial perfusion was lower in the postmenopausal than the premenopausal group (77 3 vs. 89 3 ml·100 g1·min1; P 0.01), while adenosine-induced myocardial perfusion was not different (P 0.81). After exercise training, resting myocardial perfusion was lower in both groups (66 2; P 0.002 vs. 81 3 ml·100 g1·min1; P 0.03). The adenosine-induced change in myocardial perfusion was lower in the groups combined (by 402 17 ml·100 g1·min1; P 0.02), and the adenosine-induced increase in heart rate was 10 2 beats/min lower (P 0.0001) in both groups after training. Normalization of myocardial perfusion using an estimate of cardiac work eliminated the differences in perfusion between the premenopausal and postmenopausal groups and the effect of training. Left ventricle mass was higher in both groups (P 0.03; P 0.006), whereas LV end-diastolic (P 0.02) and stroke (P 0.045) volumes were higher in the postmenopausal group after training. Twelve weeks of exercise training increased left ventricle mass and lowered resting and adenosine-induced myocardial perfusion, an effect that was likely related to cardiac work. The current data also suggest that the early menopausal transition has limited impact on cardiac function and structure. NEW & NOTEWORTHY This study provides for the first time estimates of myocardial perfusion in late premenopausal and recent postmenopausal women before and after a period of intense aerobic training. Resting myocardial perfusion was lower in postmenopausal than premenopausal women. Training lowered myocardial resting and stress perfusion in both groups, an effect that was likely influenced by the lower heart rate.

AB - We examined the influence of recent menopause and aerobic exercise training in women on myocardial perfusion, left ventricular (LV) dimension, and function. Two groups (n 14 each) of healthy late premenopausal (50.2 2.1 yr) and recent postmenopausal (54.2 2.8 yr) women underwent cardiac magnetic resonance imaging (cMRI) at baseline and after 12 wk of high-intensity aerobic training. Measurements included LV morphology, systolic function, and myocardial perfusion at rest and during an adenosine stress test. At baseline, resting myocardial perfusion was lower in the postmenopausal than the premenopausal group (77 3 vs. 89 3 ml·100 g1·min1; P 0.01), while adenosine-induced myocardial perfusion was not different (P 0.81). After exercise training, resting myocardial perfusion was lower in both groups (66 2; P 0.002 vs. 81 3 ml·100 g1·min1; P 0.03). The adenosine-induced change in myocardial perfusion was lower in the groups combined (by 402 17 ml·100 g1·min1; P 0.02), and the adenosine-induced increase in heart rate was 10 2 beats/min lower (P 0.0001) in both groups after training. Normalization of myocardial perfusion using an estimate of cardiac work eliminated the differences in perfusion between the premenopausal and postmenopausal groups and the effect of training. Left ventricle mass was higher in both groups (P 0.03; P 0.006), whereas LV end-diastolic (P 0.02) and stroke (P 0.045) volumes were higher in the postmenopausal group after training. Twelve weeks of exercise training increased left ventricle mass and lowered resting and adenosine-induced myocardial perfusion, an effect that was likely related to cardiac work. The current data also suggest that the early menopausal transition has limited impact on cardiac function and structure. NEW & NOTEWORTHY This study provides for the first time estimates of myocardial perfusion in late premenopausal and recent postmenopausal women before and after a period of intense aerobic training. Resting myocardial perfusion was lower in postmenopausal than premenopausal women. Training lowered myocardial resting and stress perfusion in both groups, an effect that was likely influenced by the lower heart rate.

KW - Faculty of Science

KW - Myocardial perfusion

KW - Menopause

KW - Cardiac MRI

KW - Exercise

U2 - 10.1152/japplphysiol.01089.2017

DO - 10.1152/japplphysiol.01089.2017

M3 - Journal article

C2 - 30870082

SN - 8750-7587

VL - 126

SP - 1272

EP - 1280

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

IS - 5

ER -