Cardiac dysfunction in cirrhosis: a 2-year longitudinal follow-up study using advanced cardiac imaging

Signe Wiese; Jens D. Hove; Silje Mo; Naja D. Mygind; Jacob Tønnesen; Claus L. Petersen; Jens Otto Clemmesen; Jens Peter Goetze; Flemming Bendtsen; Søren Møller

doi:10.1152/ajpgi.00402.2018

Cardiac dysfunction in cirrhosis: a 2-year longitudinal follow-up study using advanced cardiac imaging

Signe Wiese^*, Jens D. Hove, Silje Mo, Naja D. Mygind, Jacob Tønnesen, Claus L. Petersen, Jens Otto Clemmesen, Jens Peter Goetze, Flemming Bendtsen, Søren Møller

^*Corresponding author af dette arbejde

Abstract

The temporal relationship between cirrhotic cardiomyopathy, progression of liver disease, and survival remains unknown. Our aim was to investigate the development of structural and functional cardiac changes over time with the progression of cirrhosis and outcome. Sixty-three cirrhotic outpatients (Child class: A = 9, B = 46, C = 8) and 14 healthy controls were included in this 2-yr longitudinal study. Advanced cardiac characteristics such as cardiac MRI with extracellular volume (ECV) quantification, speckle tracking echocardiography, and biomarkers were assessed at 0/6/12/ 18/24 mo. Patients were followed-up for a median of 30 mo with registration of acute decompensations (ADs), liver transplantations (LTs), and deaths. Patients who progressed, underwent LT or died had more pronounced cardiac dysfunction, structural myocardial changes, and left atrial enlargement. Conversely, limited cardiac deterioration was seen in patients who remained stable or improved in cirrhosis. During follow-up 25 patients developed AD, 4 underwent LT, and 20 died. Mean arterial pressure was the only cardiovascular parameter associated with death in a univariate analysis (P = 0.037), and the main predictors were model for end-stage liver disease and age. However, last-visit myocardial ECV was independently associated with the combined end point of LT/death (P = 0.001), and in patients with AD a low cardiac index was independently associated with death (P = 0.01). Cardiac function seems to deteriorate with the progression of cirrhosis and affects prognosis, especially in patients with AD. Conversely, patients with stable cirrhosis have limited progression in cardiac dysfunction over a 2-yr period with modest impact on survival. The results encourage careful cardiac monitoring in advanced cirrhosis.

Originalsprog	Engelsk
Tidsskrift	American Journal of Physiology: Gastrointestinal and Liver Physiology
ISSN	0193-1857
DOI	https://doi.org/10.1152/ajpgi.00402.2018
Status	Udgivet - 1 sep. 2019

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10.1152/ajpgi.00402.2018

ajpgi.00402.2018Forlagets udgivne version, 2,24 MB

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00402.2018

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title = "Cardiac dysfunction in cirrhosis: a 2-year longitudinal follow-up study using advanced cardiac imaging",

abstract = "The temporal relationship between cirrhotic cardiomyopathy, progression of liver disease, and survival remains unknown. Our aim was to investigate the development of structural and functional cardiac changes over time with the progression of cirrhosis and outcome. Sixty-three cirrhotic outpatients (Child class: A = 9, B = 46, C = 8) and 14 healthy controls were included in this 2-yr longitudinal study. Advanced cardiac characteristics such as cardiac MRI with extracellular volume (ECV) quantification, speckle tracking echocardiography, and biomarkers were assessed at 0/6/12/ 18/24 mo. Patients were followed-up for a median of 30 mo with registration of acute decompensations (ADs), liver transplantations (LTs), and deaths. Patients who progressed, underwent LT or died had more pronounced cardiac dysfunction, structural myocardial changes, and left atrial enlargement. Conversely, limited cardiac deterioration was seen in patients who remained stable or improved in cirrhosis. During follow-up 25 patients developed AD, 4 underwent LT, and 20 died. Mean arterial pressure was the only cardiovascular parameter associated with death in a univariate analysis (P = 0.037), and the main predictors were model for end-stage liver disease and age. However, last-visit myocardial ECV was independently associated with the combined end point of LT/death (P = 0.001), and in patients with AD a low cardiac index was independently associated with death (P = 0.01). Cardiac function seems to deteriorate with the progression of cirrhosis and affects prognosis, especially in patients with AD. Conversely, patients with stable cirrhosis have limited progression in cardiac dysfunction over a 2-yr period with modest impact on survival. The results encourage careful cardiac monitoring in advanced cirrhosis.",

author = "Signe Wiese and Hove, {Jens D.} and Silje Mo and Mygind, {Naja D.} and Jacob T{\o}nnesen and Petersen, {Claus L.} and Clemmesen, {Jens Otto} and Goetze, {Jens Peter} and Flemming Bendtsen and S{\o}ren M{\o}ller",

year = "2019",

month = sep,

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doi = "10.1152/ajpgi.00402.2018",

language = "English",

journal = "American Journal of Physiology: Gastrointestinal and Liver Physiology",

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TY - JOUR

T1 - Cardiac dysfunction in cirrhosis

T2 - a 2-year longitudinal follow-up study using advanced cardiac imaging

AU - Wiese, Signe

AU - Hove, Jens D.

AU - Mo, Silje

AU - Mygind, Naja D.

AU - Tønnesen, Jacob

AU - Petersen, Claus L.

AU - Clemmesen, Jens Otto

AU - Goetze, Jens Peter

AU - Bendtsen, Flemming

AU - Møller, Søren

PY - 2019/9/1

Y1 - 2019/9/1

N2 - The temporal relationship between cirrhotic cardiomyopathy, progression of liver disease, and survival remains unknown. Our aim was to investigate the development of structural and functional cardiac changes over time with the progression of cirrhosis and outcome. Sixty-three cirrhotic outpatients (Child class: A = 9, B = 46, C = 8) and 14 healthy controls were included in this 2-yr longitudinal study. Advanced cardiac characteristics such as cardiac MRI with extracellular volume (ECV) quantification, speckle tracking echocardiography, and biomarkers were assessed at 0/6/12/ 18/24 mo. Patients were followed-up for a median of 30 mo with registration of acute decompensations (ADs), liver transplantations (LTs), and deaths. Patients who progressed, underwent LT or died had more pronounced cardiac dysfunction, structural myocardial changes, and left atrial enlargement. Conversely, limited cardiac deterioration was seen in patients who remained stable or improved in cirrhosis. During follow-up 25 patients developed AD, 4 underwent LT, and 20 died. Mean arterial pressure was the only cardiovascular parameter associated with death in a univariate analysis (P = 0.037), and the main predictors were model for end-stage liver disease and age. However, last-visit myocardial ECV was independently associated with the combined end point of LT/death (P = 0.001), and in patients with AD a low cardiac index was independently associated with death (P = 0.01). Cardiac function seems to deteriorate with the progression of cirrhosis and affects prognosis, especially in patients with AD. Conversely, patients with stable cirrhosis have limited progression in cardiac dysfunction over a 2-yr period with modest impact on survival. The results encourage careful cardiac monitoring in advanced cirrhosis.

AB - The temporal relationship between cirrhotic cardiomyopathy, progression of liver disease, and survival remains unknown. Our aim was to investigate the development of structural and functional cardiac changes over time with the progression of cirrhosis and outcome. Sixty-three cirrhotic outpatients (Child class: A = 9, B = 46, C = 8) and 14 healthy controls were included in this 2-yr longitudinal study. Advanced cardiac characteristics such as cardiac MRI with extracellular volume (ECV) quantification, speckle tracking echocardiography, and biomarkers were assessed at 0/6/12/ 18/24 mo. Patients were followed-up for a median of 30 mo with registration of acute decompensations (ADs), liver transplantations (LTs), and deaths. Patients who progressed, underwent LT or died had more pronounced cardiac dysfunction, structural myocardial changes, and left atrial enlargement. Conversely, limited cardiac deterioration was seen in patients who remained stable or improved in cirrhosis. During follow-up 25 patients developed AD, 4 underwent LT, and 20 died. Mean arterial pressure was the only cardiovascular parameter associated with death in a univariate analysis (P = 0.037), and the main predictors were model for end-stage liver disease and age. However, last-visit myocardial ECV was independently associated with the combined end point of LT/death (P = 0.001), and in patients with AD a low cardiac index was independently associated with death (P = 0.01). Cardiac function seems to deteriorate with the progression of cirrhosis and affects prognosis, especially in patients with AD. Conversely, patients with stable cirrhosis have limited progression in cardiac dysfunction over a 2-yr period with modest impact on survival. The results encourage careful cardiac monitoring in advanced cirrhosis.

U2 - 10.1152/ajpgi.00402.2018

DO - 10.1152/ajpgi.00402.2018

M3 - Journal article

C2 - 31216181

SN - 0193-1857

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

ER -

Cardiac dysfunction in cirrhosis: a 2-year longitudinal follow-up study using advanced cardiac imaging

Abstract

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