Carbon monoxide in chronic uraemia related to erythropoietin treatment and smoking habits

P Thunedborg; A L Nielsen; H Brinkenfeldt; J Brahm; H A Jensen

Carbon monoxide in chronic uraemia related to erythropoietin treatment and smoking habits

P Thunedborg, A L Nielsen, H Brinkenfeldt, J Brahm, H A Jensen

ICMM Afdeling 8

7 Citationer (Scopus)

Abstract

In 69 patients on chronic haemodialysis, blood sampled randomly during dialysis was analyzed for carboxyhaemoglobin (COHb). The median value was 1.40% (range 0.9-2.3) in non-smoking patients and (1.4-7.5) in smokers. In non-smokers treated with erythropoietin (EPO) correlation was found between COHb and the weekly EPO dose (r = 0.57, p = 0.007). In smoking patients not given EPO, the COHb correlated well with the number of cigarettes smoked (r = 0.84, p = 0.003). The COHb values did not correlate to the haemoglobin values. It is concluded that COHb levels in uraemic non-smokers are elevated because of increased endogenous CO production from the enhanced erythrocyte turnover. As even low COHb levels may negatively influence the oxygen status of the uraemic patient, the addition of exogenous CO from cigarette smoking should be avoided.

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Urology and Nephrology
Vol/bind	29
Udgave nummer	1
Sider (fra-til)	21-5
Antal sider	5
ISSN	0036-5599
Status	Udgivet - mar. 1995

Citationsformater

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title = "Carbon monoxide in chronic uraemia related to erythropoietin treatment and smoking habits",

abstract = "In 69 patients on chronic haemodialysis, blood sampled randomly during dialysis was analyzed for carboxyhaemoglobin (COHb). The median value was 1.40% (range 0.9-2.3) in non-smoking patients and (1.4-7.5) in smokers. In non-smokers treated with erythropoietin (EPO) correlation was found between COHb and the weekly EPO dose (r = 0.57, p = 0.007). In smoking patients not given EPO, the COHb correlated well with the number of cigarettes smoked (r = 0.84, p = 0.003). The COHb values did not correlate to the haemoglobin values. It is concluded that COHb levels in uraemic non-smokers are elevated because of increased endogenous CO production from the enhanced erythrocyte turnover. As even low COHb levels may negatively influence the oxygen status of the uraemic patient, the addition of exogenous CO from cigarette smoking should be avoided.",

keywords = "Adult, Aged, Carbon Monoxide, Chronic Disease, Erythropoietin, Female, Humans, Longitudinal Studies, Male, Middle Aged, Renal Dialysis, Smoking, Uremia",

author = "P Thunedborg and Nielsen, {A L} and H Brinkenfeldt and J Brahm and Jensen, {H A}",

year = "1995",

month = mar,

language = "English",

volume = "29",

pages = "21--5",

journal = "Scandinavian Journal of Urology",

issn = "2168-1805",

publisher = "Taylor & Francis",

number = "1",

}

TY - JOUR

T1 - Carbon monoxide in chronic uraemia related to erythropoietin treatment and smoking habits

AU - Thunedborg, P

AU - Nielsen, A L

AU - Brinkenfeldt, H

AU - Brahm, J

AU - Jensen, H A

PY - 1995/3

Y1 - 1995/3

N2 - In 69 patients on chronic haemodialysis, blood sampled randomly during dialysis was analyzed for carboxyhaemoglobin (COHb). The median value was 1.40% (range 0.9-2.3) in non-smoking patients and (1.4-7.5) in smokers. In non-smokers treated with erythropoietin (EPO) correlation was found between COHb and the weekly EPO dose (r = 0.57, p = 0.007). In smoking patients not given EPO, the COHb correlated well with the number of cigarettes smoked (r = 0.84, p = 0.003). The COHb values did not correlate to the haemoglobin values. It is concluded that COHb levels in uraemic non-smokers are elevated because of increased endogenous CO production from the enhanced erythrocyte turnover. As even low COHb levels may negatively influence the oxygen status of the uraemic patient, the addition of exogenous CO from cigarette smoking should be avoided.

AB - In 69 patients on chronic haemodialysis, blood sampled randomly during dialysis was analyzed for carboxyhaemoglobin (COHb). The median value was 1.40% (range 0.9-2.3) in non-smoking patients and (1.4-7.5) in smokers. In non-smokers treated with erythropoietin (EPO) correlation was found between COHb and the weekly EPO dose (r = 0.57, p = 0.007). In smoking patients not given EPO, the COHb correlated well with the number of cigarettes smoked (r = 0.84, p = 0.003). The COHb values did not correlate to the haemoglobin values. It is concluded that COHb levels in uraemic non-smokers are elevated because of increased endogenous CO production from the enhanced erythrocyte turnover. As even low COHb levels may negatively influence the oxygen status of the uraemic patient, the addition of exogenous CO from cigarette smoking should be avoided.

KW - Adult

KW - Aged

KW - Carbon Monoxide

KW - Chronic Disease

KW - Erythropoietin

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Renal Dialysis

KW - Smoking

KW - Uremia

M3 - Journal article

C2 - 7618046

SN - 2168-1805

VL - 29

SP - 21

EP - 25

JO - Scandinavian Journal of Urology

JF - Scandinavian Journal of Urology

IS - 1

ER -

Carbon monoxide in chronic uraemia related to erythropoietin treatment and smoking habits

Abstract

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