Cancer systems biology: Harnessing off-target effects

Gaye Saginc; Franziska Voellmy; Rune Linding

doi:10.1038/nchembio.2519

Cancer systems biology: Harnessing off-target effects

Gaye Saginc, Franziska Voellmy, Rune Linding^*

^*Corresponding author af dette arbejde

5 Citationer (Scopus)

Abstract

The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action

Originalsprog	Engelsk
Tidsskrift	Nature Chemical Biology
Vol/bind	13
Udgave nummer	12
Sider (fra-til)	1204-1205
Antal sider	2
ISSN	1552-4450
DOI	https://doi.org/10.1038/nchembio.2519
Status	Udgivet - 21 nov. 2017

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10.1038/nchembio.2519

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title = "Cancer systems biology: Harnessing off-target effects",

abstract = "The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action",

author = "Gaye Saginc and Franziska Voellmy and Rune Linding",

year = "2017",

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TY - JOUR

T1 - Cancer systems biology

T2 - Harnessing off-target effects

AU - Saginc, Gaye

AU - Voellmy, Franziska

AU - Linding, Rune

PY - 2017/11/21

Y1 - 2017/11/21

N2 - The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action

AB - The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action

U2 - 10.1038/nchembio.2519

DO - 10.1038/nchembio.2519

M3 - Letter

C2 - 29161245

AN - SCOPUS:85034819030

SN - 1552-4450

VL - 13

SP - 1204

EP - 1205

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 12

ER -

Cancer systems biology: Harnessing off-target effects

Abstract

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