Cancer-associated lysosomal changes: friends or foes?

T Kallunki; O D Olsen; Marja Jaattela

doi:10.1038/onc.2012.292

Cancer-associated lysosomal changes: friends or foes?

T Kallunki, O D Olsen, Marja Jaattela

Morphogenesis and Differentiation Program

152 Citationer (Scopus)

Abstract

Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic changes in lysosomal volume, composition and cellular distribution. Depending on one's point of view, the cancer-associated changes in the lysosomal compartment can be regarded as friends or foes. Most of them are clearly transforming as they promote invasive growth, angiogenesis and drug resistance. The same changes can, however, strongly sensitize cells to lysosomal membrane permeabilization and thereby to lysosome-targeting anti-cancer drugs. In this review we compile our current knowledge on cancer-associated changes in lysosomal composition and discuss the consequences of these alterations to cancer progression and the possibilities they can bring to cancer therapy.

Originalsprog	Engelsk
Tidsskrift	Oncogene
Vol/bind	32
Udgave nummer	16
Sider (fra-til)	1995-2004
Antal sider	10
ISSN	1476-5594
DOI	https://doi.org/10.1038/onc.2012.292
Status	Udgivet - 18 apr. 2013

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10.1038/onc.2012.292

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title = "Cancer-associated lysosomal changes: friends or foes?",

abstract = "Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic changes in lysosomal volume, composition and cellular distribution. Depending on one's point of view, the cancer-associated changes in the lysosomal compartment can be regarded as friends or foes. Most of them are clearly transforming as they promote invasive growth, angiogenesis and drug resistance. The same changes can, however, strongly sensitize cells to lysosomal membrane permeabilization and thereby to lysosome-targeting anti-cancer drugs. In this review we compile our current knowledge on cancer-associated changes in lysosomal composition and discuss the consequences of these alterations to cancer progression and the possibilities they can bring to cancer therapy.",

author = "T Kallunki and Olsen, {O D} and Marja Jaattela",

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TY - JOUR

T1 - Cancer-associated lysosomal changes

T2 - friends or foes?

AU - Kallunki, T

AU - Olsen, O D

AU - Jaattela, Marja

PY - 2013/4/18

Y1 - 2013/4/18

N2 - Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic changes in lysosomal volume, composition and cellular distribution. Depending on one's point of view, the cancer-associated changes in the lysosomal compartment can be regarded as friends or foes. Most of them are clearly transforming as they promote invasive growth, angiogenesis and drug resistance. The same changes can, however, strongly sensitize cells to lysosomal membrane permeabilization and thereby to lysosome-targeting anti-cancer drugs. In this review we compile our current knowledge on cancer-associated changes in lysosomal composition and discuss the consequences of these alterations to cancer progression and the possibilities they can bring to cancer therapy.

AB - Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic changes in lysosomal volume, composition and cellular distribution. Depending on one's point of view, the cancer-associated changes in the lysosomal compartment can be regarded as friends or foes. Most of them are clearly transforming as they promote invasive growth, angiogenesis and drug resistance. The same changes can, however, strongly sensitize cells to lysosomal membrane permeabilization and thereby to lysosome-targeting anti-cancer drugs. In this review we compile our current knowledge on cancer-associated changes in lysosomal composition and discuss the consequences of these alterations to cancer progression and the possibilities they can bring to cancer therapy.

U2 - 10.1038/onc.2012.292

DO - 10.1038/onc.2012.292

M3 - Journal article

C2 - 22777359

SN - 1476-5594

VL - 32

SP - 1995

EP - 2004

JO - Oncogene

JF - Oncogene

IS - 16

ER -

Cancer-associated lysosomal changes: friends or foes?

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